Primary tumors of bones are rare and composed of around 0.2% of the total load of tumors in humans. Among primary tumors, osteosarcoma is the most common primary non-hematopoietic malignancy. Giant cell-rich osteosarcoma (GCRO) is a rarest histologic variant and comprised of only 1-3% of the total burden of conventional osteosarcoma. Here, we present the case of a 16-year-old female patient with complaints of pain in the left distal thigh for 3 weeks and swelling for 1 week. The X-ray showed the lytic lesions, with a wide zone of transition over the meta-diaphyseal distal femur with a pathological fracture in the supracondylar area and Codman's triangle. Further investigation revealed the diagnosis of GCRO with the proximal tibia and lung metastasis. The prognosis was explained and radical amputation was planned in the form of above-knee amputation. However, in the post-operative period and before the commencement of the adjuvant therapy, the patient became dyspneic and her Glasgow coma scale started deteriorated and unfortunately, she could not be revived.

Background: Fractures of the distal end radius represent the most common upper extremity fracture. Distal end radius Fractures are recognized as very complex injuries with a variable prognosis. This type of fracture usually results from low Energy trauma in the elderly with low functional demand. Method: The present study patient with age 20 to 65 years included 90 cases of both extra articular and intraarticular distal end radius fracture treated with closed reduction and cast and closed reduction with K wire xation+ cast, it is a prospective study conducted at Gandhi medical college& associated Hamidia Hospital Bhopal between 2018 - 2020. Results: The most common mode of injury was fall on outstretched hand (65%), with male preponderance ( 60%) and right side more common in both the group. The average age in both the group was 45.90±10.16 year most common population in our study is 41.1% of age group 41-50 year. According to AO classication fracture type 2R3A2 is involved in 74.4% of the patients. Complications was higher in closed reduction with cast group. According to modied Gartland and werley scoring system results was in closed reduction with casting group3 patient had excellent ,9 patient had good , 28 patient had Fair and 5 patient had poor results. In closed reduction with percutaneous K Wire and casting group 7 patient had excellent , 19 patient had good , 15 patient had fair and 4 patient had poor results. Conclusions: Percutaneous Kirschner wire pinning is a minimally invasive technique that provides an effective means of Maintaining the anatomical fracture reduction. It does not required highly skilled personnel or sophisticated tools for Application. It is a suitable method for xation of displaced distal end radius fracture with minimal intra-articular Involvement. Hence we concluded that closed reduction with K-wire with cast was less complications and had better functionally as well as radiological outcome