Epilepsy is the most common of the neurological conditions that are widely affecting most of the population around the world. It is a condition on its own and a symptom of other neurological conditions too. It affects almost one per cent of the human population. Many synthetic drugs are produced to treat epilepsy effectively in various mechanisms. Few of them are Barbiturates like phenobarbitone and barbital sodium, hydantoin derivatives like Phenytoin, Sedatives and azepam derivatives like Diazepam etc. Many drugs treat epilepsy but are not devoid of side effects as discussed. So herbs are supporting the system of medicine to treat epilepsy but don't have side effects and adverse effects. There are a lot of herbs that are used to treat the disease on among them is Datura stromonium. In this work, the comparison between the antiepileptic property of the different parts of Datura was investigated, which included Flowers, Leaves, Stems and Fruits. The activity was investigated in electrical shock method to induce epilepsy. The brain enzymes were used as estimating parameters. Overall, the flowers showed very less activity compared to stems followed by fruits, and leaves of the plant Datura stramonium showed the highest activity.
Cholesterol and lipids are the major class of metabolites that are used to store high energy in the form of fats in the body. They are often stored in specific places in the system and some times misplaced in the bloodstream and other areas leading to metabolic disorders. The elevation in their quantities in serum is often termed as Hyperlipidemia. It affects most the worlds population adversely and is the causative factor for many comorbidities. Usually, medicinal plants exhibit the activities which are mainly due to the chemical constituents in them that are mostly phenols and flavonols. The plant Luffa aegiptiaca was investigated for its hyperlipidemic activity in high-fat diet-induced diabetes method. The results showed hyperlipidemic activity by lowering the lipid levels in the serum Four parts of the plant Luffa aegiptiaca were investigated for the antihyperlipidemic activity by extracting them with ethanol. These were tested for the lipid reducing property in the rat models induced by poloxamer drug. There was a successful induction of the Hyperlipidemia in the animals. The extracts showed a significant activity int his model. Fruits and leaves showed the best activity compared to other parts.
Seizures are an important and most common disease that affects the human body and are also caused to other neurological manifestations. Most of the people affected in the world currently are middle-aged and are suffering from many brain diseases. 50million people are affected due to epilepsy and convulsions around the world. There are many drugs that helpful and potent against epilepsy. As discussed, they have side effects, and the only solution to avoid those effects is the investigation of herbal sources for their anti-epileptic activity. One of those potent herbs is Nardostachys jatamansi. It was investigated and proved for its anti-epileptic property. The current research was planned to compare the effects of different extracts on the anti-epileptic property. In the process, double distilled water, methanol, ethanol and acetone were used as an extraction medium, and the extracts were tested for its property. Out of all the extracts, aqueous and methanol extracts showed a better activity compared with other extracts and standard drug, Diazepam.
Fevers are considered as the most important parameters to evaluate and diagnose most of the disease conditions like inflammations, wounds and other infections. There are effective drugs that treat and control the fevers out of which NSAID's are most important ones. They cause notable side effects like gastric ulcers, gastric mucosal perforations etc. which make the use of those drugs limited. Herbs are used to treat various diseases, starting from the evolution of the human race. During this, herbs had been introduced to many types of tests and scientific investigations to prove the activities that herbs possess. The diseases that the herbs are used for are notable in the medical systems like Ayurveda and other systems. The need for the validation of the activities of the herbs and medicinal plants is utmost important these days. The extracts of the plant leaves of Desmodium gangeticum were extracted with ethanol and then investigated for the antipyretic activity in yeast induced pyretic method. The extract was tested in two doses 200 and 400mg/kg. This was found significant when compared to the standard drug.
Seas assets that give us a variety of characteristic items to control bacterial, contagious and viral ailment and mostly utilized for malignancy chemotherapy practically from spineless creatures, for example, bryozoans, wipes, delicate corals, coelenterates, ocean fans, ocean bunnies, molluscs and echinoderms. In the previous 30 - 40 years, marine plants and creatures have been the focal point of overall endeavours to characterize the regular results of the marine condition. Numerous marine characteristic items have been effectively exceptional to the last phases of clinical preliminaries, including dolastatin-10, a group of peptides disengaged from Indian ocean rabbit, Dollabella auricularia. Ecteinascidin-743 from mangrove tunicate Ecteinascidia turbinata, Didemnins was isolated from Caribbean tunicate Trididemnum solidum and Conopeptides from cone snails (Conus sp.), and a developing number of up-and-comers have been chosen as promising leads for expanded pre-clinical appraisals. Sea anemones possess numerous tentacles containing stinging cells or cnidocytes. The stinging cells are equipped with small organelles known as nematocysts. The two species of sea anemones namely, Heteractis magnificaandStichodactyla haddoni, were collected from Mandapam coastal waters of Ramanathapuram district, Tamilnadu, India. The Nematocyst was collected and centrifuged, and the supernatant was lyophilized and stored for further analysis. The amount of protein from Heteractis Magnifica and Stichodactyla haddoni was estimated. The crude extract has shown haemolytic activity on chicken blood and goat blood. In the antibacterial activity of the sea anemone against six bacterial strains Staphylococcus aureus, Salmonella typhii, Salmonella paratyphii, Klebsiella pneumonia, Vibrio cholerae, Pseudomonas aeruginosa. Antibacterial activity of H. Magnifica and S.haddoni was measured as the radius of the zone of inhibition.
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