The first synthetic approach towards the cytotoxic agent, 7‐O‐methylnigrosporolide is described in 13 linear steps with 10.5% overall yield. The synthesis started from commercially available starting materials, D‐mannitol and 5‐hexenol. The key features of the synthetic pathway involved are Hydrolytic Kinetic Resolution, C2‐Wittig, CBS reduction, Horner‐Wadsworth‐Emmons reaction, Shiina macrolacto‐nization and Lindlar reduction.

Synthesis of natural products, Artekeiskeanol B and D are described. The important protocols involved in the synthesis are oxidative C-C bond cleavage, Still-Gennari olefination, debenzylation and Mitsunobu etherification. The synthesis was started from commercially available Geraniol and 2,4-dihydroxy benzaldehyde.

The concise enantioselective total synthesis of antiviral agents (+)-sattazolin and (+)-sattabacin are described in six steps. This synthetic strategy started from commercially available isovaleraldehyde and the key reactions involved in this synthesis are Sharpless epoxidation, phenyl Grignard, Eu(III) catalyzed ring opening of chiral epoxide with indole.

A formal stereoselective synthesis of the naturally occurring 16-membered macrolide aspergillide D is described. The origins of the chiral centers are ribose, lactic acid and the Sharpless asymmetric epoxidation protocol. The foremost reactions involved are Yadav's protocol, the Ohira-Bestmann reaction and alkyl-iodide coupling.

The total syntheses of artekeiskeanol A and C, and altissimacoumarin D have been achieved. The syntheses commenced from commercially available starting materials, 2,4-dihydroxybenzaldehyde and geraniol. The key steps involve Wittig and Riley oxidation reactions.