A new family of two-dimensional (2D) materials called MXenes has gained attention recently owing to their fascinating physical and chemical properties.Herein, 2D vanadium carbide (V 2 C) MXene was mixed with cellulose nanocrystals (CNCs) to produce an environmentally friendly V 2 C/CNC composite.The V 2 C/CNC composite exhibited surface-enhanced Raman scattering (SERS) activity for the methylene blue (MB) dye with an enhancement factor of $9 Â 10 5 . Here, we have proposed that along with electromagnetic enhancement, the charge transfer process plays a vital role in the SERS enhancement. We believe that this work would open a new way to fabricate sustainable and renewable MXene and CNC composite solution-based SERS platforms for analyte detection.