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Background Intestinal failure patients dependent on parental nutrition are reliant on central venous catheters and are at increased risk for central line–associated bloodstream infection (CLABSI). Seventy percent ethanol has been widely used for prophylaxis; however, it is known to have multiple adverse effects. This study demonstrates the implementation of a 30% ethanol lock protocol for CLABSI prevention in a community‐based hospital intestinal rehabilitation program. Methods This case series reports rates of CLABSI, compromised central venous catheter, and analysis of community bacterial pathogens. Results A 42.1% increase in CLABSI and a 125% increase in compromised central venous catheters were noted after initiation of the 30% ethanol lock protocol. Conclusion It can be concluded that for the pediatric intestinal rehabilitation patient, 30% ethanol did not provide adequate CLABSI prophylaxis. This study indicates the need for larger sample sizes or the use of other concentrations of ethanol locks ranging between 30% and 70%.

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