ABSTRAKProses produksi sel darah (hematopoiesis) pada kondisi normal diformulasikan dalam bentuk sistem persamaan diferensial nonlinier dengan waktu perlambatan. Waktu perlambatan menunjukkan durasi atau waktu yang diperlukan sel punca berada pada fase proliferasi. Penelitian ini bertujuan untuk menganalisis model matematika pada proses produksi sel darah meliputi analisis titik tetap dan perilaku populasi sel punca hematopoietik. Untuk mempelajari perilaku dinamik model, dilakukan dengan mempelajari persamaan karakteristik dari model tersebut. Hasil simulasi numerik menunjukkan bahwa untuk titik tetap nontrivial model mengalami osilasi. Osilasi pada model matematika proses hematopoiesis mengindikasikan bahwa hematopoiesis yang terjadi tidak stabil sehingga nantinya dapat diimplementasikan pada analisa adanya penyakit-penyakit yang mempengaruhi sel darah.Kata Kunci: Hematopoiesis, osilasi, model matematika, waktu perlambatan ABSTRACT Blood cell production process (hematopoiesis) in normal conditions is formulated in the form of a nonlinear differential equation system with time delay. Time delay indicates the duration or time required for stem cells in the proliferative phase. This study aims to analyze the mathematical model of blood cell production process including fixed point analysis and hematopoietic stem cell population behavior. Studying the characteristics equations of the model was conducted to study the dynamic behavior of the model. The numerical simulation results show that for nontrivial fixed point model experiences oscillations. Oscillations in mathematical models of hematopoiesis process indicate that hematopoiesis occurs unstable so that they can be implemented on an analysis of the presence of diseases that affect blood cells.
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