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Diabetes mellitus has been emerged as one of the major health problems, which is found commonly all over the world. In Ayurveda, inclusion of Madhumeha, in eight major diseases (Ashthamahagada) indicates the gravity and significant attributed to it. In this study a comparative trial between an Ayurvedic compound (Kalpit) named as Madhudaman Yoga, and Glipizide as control drug was carried out. 50 patients of Diabetes mellitus were registered from the OPD and IPD of NIA, Jaipur for this study. These patients were divided into two groups.  Group A (control drug) – 25 patients took Glipizide 5 mg twice daily for 75 days. Group B (trial drug) - 25 patients took 2 capsules of Madhudaman Yoga 500 mg, twice daily for 75 days. At the end of the study it was observed that the trial drug showed significant improvement in FBS, PPBS, and HbA1c (p<0.001). Significant relieves in many symptoms were also observed. The overall effect of Madhudaman Yoga was approximately similar to that of the control drug. No side effects were noticed in any of the patients of the trial group.