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The presence of crystalline inclusions in plasma cell myeloma is a rare phenomenon and cases have been reported with rod, needle, and rectangular shaped crystals in the bone marrow. Here, we present a case of plasma cell myeloma with intracellular crystalline eosinophilic inclusions and extracellular crystal depositions in the bone marrow. Since crystal depositions can be seen in many other clinical conditions, this case invites consideration of plasma cell myeloma in the differential diagnosis of patients with crystalline deposition in the bone marrow and in sites/organs other than the bone marrow.

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