Adoption of an integrated farming system (IFS) is essential to achieve food and nutritional security in small and marginal holdings. Assessment of IFS to know the resource availability and socio-economic condition of the farm household, farm typology plays a critical role. In this regard, a sample survey of 200 marginal households practicing mixed crop-livestock agriculture was conducted during 2018–2019 at Southern Coastal Plains, which occupies 19,344 ha in Thiruvananthapuram district, Kerala, India. Farming system typology using multivariate statistical techniques of principal component analysis and cluster analysis characterized the diverse farm households coexisting within distinct homogenous farm types. Farming system typology identified four distinct farm types viz. resource constrained type-1 households with small land owned, high abundance of poultry, very low on-farm income, constituted 46.5%; resource endowed type-2 households oriented around fruit and vegetable, plantation crop, with a moderate abundance of large ruminant and poultry, high on-farm income, constituted 12.5%; resource endowed type-3 household oriented around food grain, extensive use of farm machinery, with a moderate abundance of large ruminant, low on-farm income, constituted 21.5%; and resource endowed type-4 household oriented around fodder, with high abundance of large ruminant, medium on-farm income, constituted 19.5% of sampled households. Constraint analysis using constraint severity index assessed the severity of constraints in food grain, horticulture, livestock, complementary and supplementary enterprises in each farm type, which allowed targeted farming systems interventions to be envisaged to overcome soil health problems, crops and animal production constraints. Farming system typology together with constraint analysis are therefore suggested as a practical framework capable of identifying type-specific farm households for targeted farming systems interventions.