Measurements with the DCT showed good concordance with intracameral IOP. CCT exerted a statistically significant but clinically irrelevant effect on measurements with the DCT.

Abstract.Objective: Fronto-striatal dysfunction has been discussed as underlying symptoms of Tourette syndrome (TS) with co-morbid Obsessive Compulsive Disorder (OCD). This suggests possible impairments of executive functions in this disorder, which were therefore targeted in the present study. Methods: A comprehensive series of neuropsychological tests examining attention, memory and executive functions was performed in a group of 14 TS/OCD in co-occurrence with OCD patients and a matched control group. Results: While attentional and memory mechanisms were not altered, TS/OCS patients showed deficits in executive functions predominately in the areas of response inhibition and action monitoring. Conclusions: These findings provide further evidence for a substantial impairment of the frontal-striatal-thalamic-frontal circuit. We propose that the deficits in monitoring, error detection and response inhibition constitute the major impairment of TS/OCD patients in the cognitive domain.

In many patients the Gilles de la Tourette Syndrome (TS) is associated with the childhood Attention Deficit Hyperactivity Disorder. To gain a general view of attentional processes in TS we recorded event-related brain potentials (ERPs) in 12 TS patients and in a matched control group. Four visual attention experiments with different levels of complexity were done (oddball task, pop-out experiment, figure extraction and figure conjunction task). The reaction times did not differ significantly between groups. The Tourette patients' event-related brain potentials showed an increased amplitude of the N2 component to targets in the simple oddball and pop-out experiments. While both groups had similar P3b latencies to targets in the figure extraction experiment, Tourette patients responded less accurately in the most complex figure conjunction task and had increased P3b latencies. This is interpreted as evidence for a stronger attentional effort of the Tourette patients to obtain behavioural results similar to control subjects in easy attentional tasks. Consequently, Tourette patients show a reduced performance in complex attentional tasks.