Introduction The novel Coronavirus has caused major disruptions to sleep and cognitive function of many individuals. The present study evaluated the degree to which daytime cognitive dysfunction may be related to worsening sleep. Methods Data from adults aged 18 and older in the 2020 Coronavirus and Impact on Dreams (CovID) study were used. Individuals were asked “how would you rate your sleep quality overall” and answered with “very good, fairly good, fairly bad, or very bad.” Subjects were asked if it takes “30 minutes or more to fall asleep” and answered with how frequently that happened. In addition, participants were asked how often they wake up during the night. Participants were then asked how much they think their sleep problems have contributed to daytime functioning and answered on a scale of 0 to 5, from “not at all” to “very much,” respectively. Results 46% of the sample did not report problems with daytime cognitive function, while 33%, 12%, and 9% reported mild, moderate, and severe problems, respectively. Those who reported that they have kept a regular schedule during the pandemic were 83% less likely to report greater daytime cognitive dysfunction (95%CI:0.08,0.37, p<0.0005). Those who indicated that overall their sleep worsened or improved did not demonstrate a difference in likelihood of daytime cognitive problems. Regarding specific sleep experiences, those who reported more problems falling asleep due to the pandemic were 8.2 times more likely to report daytime cognitive dysfunction (95%CI:3.53,19.07, p<0.0005) and those who reported more problems with morning awakenings were 5.7 times more likely (95%CI:2.10,15.56, p<0.001). Those who reported that they were sleepier as a result of the pandemic were 9.3 times as likely to report daytime cognitive dysfunction (95%CI:3.53,24.46, p<0.0005) and those who reported taking more naps were 4.4 times more likely (95%CI:1.90,10.40, p<0.001). Conclusion In general, people who reported increased sleepiness, a less regular schedule, more insomnia, and more napping were more likely to experience daytime cognitive dysfunction during the COVID-19 pandemic. Support (if any) R01MD011600, R01DA051321

Introduction Poor sleep has been shown to be related to suicide ideation and depressed mood, but population-level studies have not been done to explore the specific issues within sleep that effect mood, specifically leading to suicide ideation. Methods Data from adults 18 and older in the 2015-2016 National Health and Nutrition Examination Survey (NHANES) who provided complete data were used (N=5,123). Suicide ideation was recorded as the presence of thinking that “you would be better off dead” in the past 2 weeks. Sleep duration was recorded in half-hour increments and transformed to represent absolute distance from 7 hours (to model u-shaped association). Sleep disturbance was recorded as presence of “difficulty falling asleep, staying asleep, or sleeping too much” non, several days, or more than half the days of the past 2 weeks. Sleepiness was frequency feeling “overly sleepy during the day” in the past 12 months. Covariates included age, sex, race/ethnicity, and presence of depressed mood in the past 2 weeks. Additional impact of difficulty thinking/concentrating in the past 2 weeks was explored. NHANES sample weights were used in analyses. Results In adjusted analyses, increase likelihood of suicide ideation was associated with distance from 7hrs (OR=1.24/hr, p=0.008), sleep difficulties most of the time (OR=2.46, p=0.001), but not sleepiness. When both sleep variables were adjusted for each other, results remained significant for U-shaped sleep duration (OR=1.21/hr, p=0.02) and sleep disturbance (OR=2.31, p=0.003). These were attenuated but remained significant when difficulty thinking/concentrating was introduced; a significant sobel test (p<0.0001) suggested partial mediation, with this variable accounting for approximately 13% of the variance of the relationship to sleep. Conclusion In the population, improper and poor sleep was associated with a greater risk of suicide ideation. Support Dr. Grandner is supported by R01MD011600

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