Objectives:Triclofos may be a better sedative in view of better palatability and less gastric irritation as compared to chloral hydrate. This study aimed to assess the efficacy of triclofos (a commonly used sedative in India) as a sedative for sleep electroencephalogram (EEG) study in children.Methods:This prospective observational study was carried out in a tertiary care pediatric center. Consecutive children aged 6 months to 5 years referred for sleep EEG evaluation were recruited. Their clinical details were noted in a proforma after an informed consent. After a trial for natural sleep, oral triclofos was administered. Sleep parameters and adverse effects were noted.Results:One-hundred and sixty children were then enrolled. EEG was successfully recorded in 149 (93.1%) children. Median latency of sleep onset was 30 min and median duration of sleep was 90 min. The adverse effects in the following 24 h were mild and included dizziness, irritability, and vomiting.Conclusions:Oral triclofos was found to be an effective sedative for EEG in children with minimal adverse effects.
Serial plates are not reasonable in material saving and stress dispersion. To design orthopedic plates ideally and conveniently, this paper proposes a method to optimize plates through editing semantic parameters based on average bone model. Firstly, for the reasonable distribution of serial plates in number and size, an average bone model is created from the existing bones, among which each bone has a contribution to the average model. Secondly, a common orthopedic plate with semantic parameters is constructed on average bone model and it can be conveniently modified. Lastly, optimizing the thickness of the plate through finite element analysis and genetic algorithm to meet the stress condition and use as little material as possible. The simulation results indicate that the method can save material and disperse the stress of the plates so that it can effectively optimize the orthopedic plates.
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