Contrast enhancement (CE), contrast extravasation (CX), hemorrhagic transformation (HT), and cerebral hyperperfusion syndrome (CHS) in patients who have suffered ischemic stroke and have undergone revascularization. There are a handful of articles addressing these pathologies separately. But there is scant literature available combining them together, as the underlying pathophysiology involves disturbances of blood–brain barrier (BBB). We have reviewed literature and proposed a common mechanism for these events. We systematically searched PubMed, LibGen, Cochrane, and Sci-Hub databases for the studies published online regarding CE, CX, HT, and CHS after endovascular treatment for stroke. This review was conducted based on the PRISMA guidelines. The following medical search terms were used for the online search: contrast enhancement, contrast extravasation, hemorrhagic transformation, cerebral hyperperfusion syndrome, endovascular treatment, contrast staining, postprocedural attenuation, carotid stenting, intra-arterial thrombolysis, and stroke. We did a limited review of literature by analyzing the relevant articles and research papers published to date. We have randomly included prototype cases of CE, CX, HT, and CHS which we have encountered in our Interventional Department from our own database. In compliance with PRISMA guidelines, we screened 33 articles dealing with CE, 32 with CX, 26 articles that addressed CE and CX both, 53 articles dealing with HT, and 42 articles dealing with CHS. Overall, 88 articles were filtered on studying the abstract. Further, 15 more had to be excluded as reasoned in the flowchart, and finally 71 articles were included in our study, as again shown in the flowchart. We studied and discussed these articles and research papers in relation to pathophysiology, predisposing factors, preventive measures, and current treatment protocols. BBB disruption is the primary event in CE, CX, HT, and CHS with varying severity. Minimizing dose of contrast, optimum timing of revascularization and dose of thrombolytic, judicious selection of mechanical thrombectomy cases, and strict control of blood pressure in postrevascularization period are recommended preventive measures. High-index of clinical suspicion, early imaging to detect, and following-up the same on sequential imaging are key to avoid severe forms of HT and CHS.