No abstract

In today's software industry, technological prowess and ever-evolving customer requirements have led to more complex software demands. Agile based software development is increasingly being adopted by the software practitioners as it assures early software development and high quality software products. Also, it offers responsiveness to changes in user requirements, providing for their quick absorption during software development. In this paper, we elaborate the significance, benefits and increasing adoption of Agile methodologies in context of today's complex and evolving software demands. The main objective of this paper is to conduct an empirical study into the choice among the most popular Agile methodologies, Scrum, Extreme Programming and Kanban. Further, this paper provides for a comparative analysis among various agile software development methodologies. Our survey results reveal higher adoption of Scrum based development in present-day software industry as compared to Extreme Programming and Kanban methodologies.

New bidentate or tridentate Schiff bases and their VO(II) and Co(II) complexes formed by the condensation of methyl isobutyl ketone with nicotinamide (mna)/2-amino-4-chlorophenol (map) and 2-hydroxy acetophenone with nicotinamide (han)/isoniazide (hai). Physicochemical characterization has been carried out to determine the structure of the complexes. The FAB mass and thermal data show degradation pattern of the complexes. XRD analysis reveals that all the studied complexes crystallize as tetragonal crystal system. Some of the complexes have been screened for their antimicrobial activity by the well diffusion technique using DMSO as solvent on different species of pathogenic bacteria/fungi, that is, E. coli, S. aureus, S. fecalis, A. niger, T. polysporum, and their antimicrobial potency have been discussed. It has been found that all the complexes are antimicrobially active and show higher activity than the free ligand. Metal chelation affects significantly the antimicrobial/bioactive behavior of the organic ligands.

Complexes of Co(II), Ni(II) and Cu(II) with the Schiff bases salicylidene-2-aminophenol (H 2 SAPh), furfurylidene-N-phenylthiourea (FNPTU) and salicylidene-N-phenylthiourea (HSNPTU) have been synthesized and their physico-chemical properties have been investigated with the help of microanalytical data, UV-Vis, IR, ESR spectroscopy, TGA, conductance and magnetic susceptibility measurements. Non-isothermal kinetic

Pyoderma gangrenosum (PG) is an uncommon noninfectious neutrophilic dermatosis characterized by recurrent, sterile, necrotic skin ulcers. It is commonly associated with underlying systemic disease like inflammatory bowel disease, rheumatoid arthritis and hematological malignancies. Pathogenesis of PG remains unclear though aberrant immune responses have been implicated. The diagnosis of PG is of exclusion and management is empirical with local or systemic immunosuppressive therapy. LAD-I is a rare form of autosomal recessive disorders caused by mutations of the gene ITGB2, clinically characterized by recurrent severe bacterial infection, impaired pus formation, poor wound healing and persistent neutrophilia. Though skin ulcerations are common, predominant clinical presentation as PG is unusual in LAD-I. Here we present four Indian patients with LAD-I from three unrelated families initially diagnosed as PG due to chronic recurrent skin ulcerations requiring steroids and antibiotics for healing, associated with atrophic scar formation. All these four patients had persistent neutrophilia without history of delayed cord separation and showed moderate expression of CD18 (19 to 68%) on neutrophils. Sequencing of the entire coding region and intronic splice sites of the ITGB2 gene from the genomic DNA of these patients revealed a novel common mutation IVS10+4A>G. LAD-I should be kept in mind while evaluating patients with PG especially those with persistent neutrophila in the absence of other rheumatological disorders. Diagnosis of LAD-I in these cases is extremely important for management as treating these patients without adequate antibiotic cover may prove fatal and these patients often require hematopoietic stem cell transplantation for permanent cure.