Background: The cell cycle of all organisms includes mass increase by a factor of two, replication of the genetic material, segregation of the genome to different parts of the cell, and cell division into two daughter cells. It is tightly regulated and typically includes cell cycle-specific oscillations of the levels of transcripts, proteins, protein modifications, and signaling molecules. Until now cell cycle-specific transcriptome changes have been described for four eukaryotic species ranging from yeast to human, but only for two prokaryotic species. Similarly, oscillations of small signaling molecules have been identified in very few eukaryotic species, but not in any prokaryote.

The first haloarchaeal genome was published in 2000 and today five genome sequences are available. Transcriptome and proteome analyses have been established for two and three haloarchaeal species, respectively, and more than 20 studies using these functional genomic approaches have been published in the last two years. These studies gave global overviews of metabolic regulation (aerobic and anaerobic respiration, phototrophy, carbon source usage), stress response (UV, X-rays, transition metals, osmotic and temperature stress), cell cycle-dependent transcript level regulation, and transcript half-lives. The only translatome analysis available for any prokaryotic species revealed that 10 and 20% of all transcripts are translationally regulated in Haloferax volcanii and Halobacterium salinarum, respectively. Very effective methods for the construction of in frame deletion mutants have been established recently for haloarchaea and are intensively used to unravel the biological roles of genes in this group. Bioinformatic analyses include both cross-genome comparisons as well as integration of genomic data with experimental results. The first systems biology approaches have been performed that used experimental data to construct predictive models of gene expression and metabolism, respectively. In this contribution the current status of genomics, functional genomics, and molecular genetics of haloarchaea is summarized and selected examples are discussed.

„Diagnose YouTube“ beschäftigt sich mit den Themen Gesundheit, Medizin, Social Media, Internet und den damit einhergehenden positiven wie auch negativen Aspekten. Unter Verwendung einschlägiger Suchbegriffe wie etwa (Internet-)Gesundheit, Medizin, Infotainment, Influencer sowie Fitness und Ernährung werden die darunter zugeordneten Inhalte in den Blick genommen. Neben der Analyse der Videos werden auch die YouTuber der Gesundheitsszene vorgestellt. Die Beschäftigung mit diesem Thema führt zu überraschenden Erkenntnissen, die im Fazit unterschiedliche Bewertungen aus mehreren Perspektiven erlauben.