The reaction of nitriles with P 2 Se 5 in the presence of EtOH/H 2 O afforded a variety of primary selenocarboxylic amides.

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Organo-selenium compoundsOrgano-selenium compounds S 0130 Efficient Synthesis of Primary Selenocarboxylic Amides by Reaction of Nitriles with Phosphorous(V) Selenide. -Nitriles react with P 4 Se 10 in an aqueous reaction medium to give good yields of selenoamides which may be converted to selenazoles with α-bromo carbonyl compounds. -(GEISLER*, K.; JACOBS, A.; KUENZLER, A.; MATHES, M.; GIRRLEIT, I.; ZIMMERMANN, B.; BULKA, E.; PFEIFFER, W.-D.; LANGER*, P.; Synlett 2002, 12,[1983][1984][1985][1986]; Inst. Chem. Biochem.,

Nach verschiedenen Methoden werden 31 4‐ und 5‐Heteroaryl‐substituierte Salicylsäuren dargestellt, von denen einige Vertreter im Formelschema angegeben sind.