Netarsudil is a relatively new medication for the treatment of primary open-angle glaucoma and ocular hypertension. It has been associated with red eyes and burning after instillation. Reticular epitheliopathy is a relatively rare complication of netarsudil that has been described in patients with preexisting corneal edema. We report the case of a healthy 76-year-old woman who developed reticular epitheliopathy after full-thickness penetrating keratoplasty that completely resolved following discontinuation of the medication. In cases where netarsudil is initiated for treatment of glaucoma or, off-label, endothelial dysfunction, reticular epithelial edema should be considered in patients complaining of a decline in vision and severe pain.

Introduction:To the authors' knowledge, this is the first reported case of netarsudil-associated reticular corneal edema noted shortly after phacoemulsification with intraocular lens (IOL) implantation. Patient and Clinical Findings:A 68-year-old woman with a history of chronic angle-closure glaucoma with a long-term history of tolerance to netarsudil presented with "honeycomb" epitheliopathy shortly after phacoemulsification with IOL implantation.Diagnosis, Intervention, and Outcomes: Netarsudil was discontinued, and the patient's reticular corneal edema resolved shortly thereafter.Conclusions: Reticular corneal epitheliopathy can be seen in patients being treated with netarsudil after phacoemulsification with IOL implantation. Fortunately, this condition resolves shortly after the drug is discontinued.