Dispersible tablets are uncoated or film-coated tablets meant to be spread in water before administration giving a unvaried dispersion. Pediatric and old patients face complications in swallowing the conventional tablets. So according to the need dispersible tablets have been developed which combine the benefits of liquid dosage forms and solid dosage forms. The dispersible tablets allow dispersion in water prior to administration. In present study we have compared three brands of different dispersible tablets. The objective of the study was to find out the best dosage form based on the post compression parameters of dispersible tablets and to develop a co-relation among these parameters. Three brands of dispersible tablets had been selected i.e. Acetylsalicylic acid, Cefixime & Paracetamol tablets and they have been compared on the basis of different parameters of dispersible tablets like uniformity of weight, friability testing, hardness, wetting time, wetting volume, water absorption ratio, dispersion time, disintegration time, uniformity of dispersion. Acetylsalicylic acid & Cefixime complies all the parameters except friability test, while Paracetamol tablets complies all the tests except it was showing more hardness compared to other two brands due to which it’s properties like wetting time, wetting volume, water absorption ratio, dispersion time, disintegration time was lower than other two. So after overall comparison Cefixime was found to be the best in comparison to other two brands. Keywords: Dispersible tablets, paracetamol, cefixime, acetylsalicylic acid, comparison, post compression parameters.

Candida spp. and Cryptococcus spp. are important fungal pathogens in cancer patients. Nonalbicans Candida are of special concern, since some are highly virulent and show reduced susceptibility to antifungal agents. Nonneoformans Cryptococcal infections have also shown an incremental rise over the past four decades. The aim of this retrospective study was to evaluate the prevalence, distribution and susceptibility pattern of various species of Candida and Cryptococcus causing infections in cancer patients. This Retrospective study was conducted from Jan 2011 to Aug 2016. Yeasts/yeast like fungi isolated in various specimens received for fungal and also bacterial culture were included. Fully automated VITEK 2 compact was used for final species identification and susceptibility testing of isolated yeasts. The prevalence of infections was 1.36% during the study period with prevalence being 0.54% in patients with haematological cancer and 2.45 in patients with Solid tumours. Among various solid tumours maximum infection rate was seen in patients with head and neck cancers i.e. 4.01%. A total of 9.09% growths were responsible for Blood Stream Infections (BSI). Most common Candida sp. isolated was C.tropicalis (37.06%) followed by C.albicans (36.87%). Out of total 35 Cryptococcus sp. isolated 30 were Cryptococcus laurentii and only 5 were Cryptococcus neoformans. Low level of resistance was shown by C.albicans to all the antifungal agents. C.tropicalis also showed low resistance with only 2.01% resistance to Fluconazole and Amphotericin B. Higher resistance rate was observed in C.krusei with 7.69% isolates resistant to Fluconazole and 15.38% resistant to Amphotericin B. Rate of resistance shown by C.glabrata to Fluconzole was also quite high i.e. 9.09%. Most of the Candida sp. showed good sensitivity to both Caspofungin and Micafungin except C.krusei with 15.38% resistance to both candins. Out of all the antifungal agents tested for Voriconazole was the most effective for all the yeasts isolated with highest resistance rate being 7.69% shown by C. krusei. All Cryptococcus neoformans isolated were sensitive to the antifungal agents tested for. i.e. Amphotericin B, Flucytosine, Fluconazole and Voriconazole. Our study emphasizes the need to make new prophylaxis policies for Candida infections. Also further studies should be conducted to determine the antifungal susceptibility pattern of Cryptococcus laurentii.

Sericin is a serine-rich polydispersed glycoprotein found in Bombyx mori's cocoons. Sericin is extracted from cocoons as a protein, composed of amino acids like aspartic acid, glycine, tyrosine, serine, and glutamic acid with carboxyl, hydroxyl, and an amino group. Sericin has been explored for various pharmacological activities such as antioxidant, anti-inflammatory, antiapoptotic, antiproliferative, antibacterial, anti-hypercholesteremia, and wound healing activity. Moreover, sericin has also been explored as a biopolymer for the preparation of nanoparticles, scaffolds, hydrogels, films, etc. This mini-review illustrates the reported methods for the characterization of extracted sericin and quantification in pharmaceutical formulations. The review covers analytical methods like UV-Visible Spectroscopy, Fourier-transform infrared spectroscopy, amino acid analysis, mass spectroscopy, and high-performance liquid chromatography with a brief explanation of every analytical method.

Polymeric micelles have opened up new horizons for improving drug delivery to brain particularly due to their small size, long circulation time, good stability and targetability. They are used to treat a variety of brain conditions, including glioblastoma, migraine, Alzheimer's, Parkinson's, and other conditions linked to the brain. Micelles are currently underutilised in brain targeting despite having several benefits and spanning a wide variety of brain illnesses. Since most medications are unable to cross the blood brain barrier, scientists are continuously working to discover efficient solutions to the problems. The most pressing issue was thought to be the viability and difficulties of translating micelles into the therapeutic setting. This review describes the role of micellar delivery system in brain diseases treatment along with their route of administration and outcomes. The review also discusses the current state of patents and clinical trials in the relevant fields and their potential future applications.