Aim and Objective: To compare the efficacy and safety of brinzolamide1% and timolol0.5% fixed combination eye drops versus dorzolamide2% and timolol0.5% fixed combination eye drops in the treatment of primary open-angle glaucoma Design: Prospective, randomized, comparative, interventional study Setting: Tertiary eye care centre. Material and Method: The present study was a comparative study carried out on patients visiting OPD of Ophthalmology Department and diagnosed with primary open-angle glaucoma. Group 1 (n-30 BT) received brinzolamide1% and timolol0.5% fixed combination eye drops, and Group 2 (N-30 DT) patients received dorzolamide2% and timolol0.5% fixed combination eye drops. A complete ophthalmic examination was performed, including Goldmann applanation tonometry. IOP was measured twice daily (9 AM and 4 PM). The patients were evaluated at 2, 4, 8, and 12 weeks. IOP was measured at follow-up. Side effects and tolerability of both drugs were assessed, and patient preference for drugs was noted Results: Mean reduction in morning IOP was significantly more in Group 1 than in Group 2 at 8 weeks and 12 weeks (p < 0.05). Mean reduction in evening IOP was significantly more in Group 1 than in Group 2 at all follow-ups (p < 0.05) Conclusion: Brinzolamide1% + timolol0.5% fixed drug combination is more preferred and effective in lowering IOP than dorzolamide2% + timolol0.5% fixed drug combination in patients of primary open-angle glaucoma.

In the present study the function of anterior chamber depth (ACD) changes in determining the refractive outcome after cataract surgery has been studied comprehensively. 210 successive adult patients going through unilateral cataract surgery (phacoemulsification by a single surgeon) were included in this prospective study. Depending on axial length patients were suitably classified into 3 groups: Group 1: <22 xss=removed xss=removed>26 mm (n = 70). Pre-operative and post-operative ACD were assessed on immersion ultrasound. The patients were arbitrarily reclassified into group A (≤1.7 mm) and B (>1.7 mm) based on mean ACD change. Post-operative emmetropic, myopic, or hypermetropic status was also determined in all patients. Mean ACD change in short eyes (Group 1), normal (Group 2), and long (Group 3) eyes was 1.90 mm, 1.75 mm, and 1.45 mm, respectively. The Hyperopic shift was noted when the change in ACD was less than 1.70 mm and Myopic shift was noted when the alteration in anterior chamber depth was more than 1.70 mm. Short eyes were more prone to greater post-operative ACD changes as compared to long eyes. Assessment of pre-operative ACD and its subsequent changes after cataract surgery may help in predicting postoperative refractive error. The lesser amount of change in ACD may result in a hyperopic shift and a higher amount of change would result in a myopic shift. Keywords: Anterior chamber depth, Axial length, Myopia, Hypermetropia, Cataract surgery.