Although the estimated rate of TAM accumulation was lower than anticipated, all possible efforts should be continued to increase the availability of drug options in RLSs.

No abstract

A routine-based Danish database for biological therapies covers approximately 90% of patients and improves the reporting of adverse events.

A self‐recording electronic osmometer for clinico‐physiological use is described. It is a further development of an osmometer described earlier by the author. It is based on the passive counter‐pressure principle and as such representing a return to the principle that was first applied in osmotic pressure measurements. The general principles for the measuring of osmotic pressure and the special requirements to be fulfilled if quick performance is to be obtained are discussed. The importance of the diffusion phenomena in this context has been emphasized and experimentally elucidated. The sample of plasma or serum which is required, is from 0.02 to 0.1 ml. Ten to 15 measurements can be performed per hour. The confidence limits for one measurement are ± 0.5 mm Hg. at the 5% level. Commercially available cellulose membranes are used. No stopcocks are employed. Stainless steel is used for all parts in contact with membrane and sample. The possible usefulness of the osmometer for investigation of the reflection coefficient of permeating particles and for testing membranes is pointed out. Also the possible use in investigations of active trans port problems in connection with organic membranes is hinted at. Finally it is mentioned that the red blood cells under certain circumstances will influence the osmotic pressure.