This article is available online at http://www.jlr.org Dyslipidemia, which is characterized by elevated cholesterol or triglycerides, is a major risk factor for coronary heart disease (as reviewed in Ref. 1 ). One of the most studied forms of dyslipidemia is familial hypercholesterolemia (FH) caused by genetic factors. Although homozygous FH is a rare condition, heterozygous FH occurs in approximately 1 in 500 people and can cause premature atherosclerotic disease (as reviewed in Ref. 2 ). Combination therapy is commonly used in clinical practice to improve hypercholesterolemia. The most commonly used combination therapy consists of statins with fi brates or niacin. However, this combination has limited additive effect on LDL cholesterol levels. Moreover, the poor tolerance of niacin and the statin-induced side effects (e.g., muscle toxicity) limit the use of this combination (as reviewed in Refs. 3 and 4 ). In addition to dyslipidemia, infl ammation by itself can lead to increased risk of coronary heart disease. Therefore, a therapeutic regimen that has the potential to reduce dyslipidemia and infl ammation would be more benefi cial in reducing cardiovascular events than treatments aimed at improving dyslipidemia alone.Fish oil (FO) containing n-3 polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid

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Abstract. In this paper, we prove almost global existence of solutions to certain quasilinear wave equations with quadratic nonlinearities in infinite homogeneous waveguides with Neumann boundary conditions. We use a Galerkin method to expand the Laplacian of the compact base in terms of its eigenfunctions. For those terms corresponding to zero modes, we obtain decay using analogs of estimates of Klainerman and Sideris. For the nonzero modes, estimates for Klein-Gordon equations, which provide better decay, are available.