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Inborn errors of immunity (IEIs), also known as primary immunodeficiencies (PIDs), are genetic disorders affecting immune system development and/or function. [1][2][3][4] They are best known for enhanced susceptibility to infections, but can also cause autoimmunity, malignancy, atopy, inflammation, and organ dysfunction. 5,6 IEIs include a wide spectrum of >430 genetically unique disorders, though they individually can be rare (eg, <1/1,000,000 in IPEX syndrome), 7,8 as a group IEI prevalence is 1:2000-1:10,000, with newer studies proposing as high as 1:1200. 9 In comparison, cystic fibrosis, a much more studied condition, has an estimated birth rate in Canada of