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Hypoestoxide, a new diterpene from Hypoestes roses (Acanthaceae) has been assigned the bicyclo[9,3.llpentadecane structure.Recent studies from our laboratories have led to the isolation of two new diterpenes from Hypoestes rosea (~canthaceae)~,~. We now wish to report the isolation and structural determination of another new bicyclo[9,3,llpentadeeane diterpene, hypoestoxide (i) from the same plant.The gum (53.6g) obtained after removal of solvent from the hexane extract of the aerial parts of 5.