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Objective: Loneliness is a well-established risk factor for suicide in young adults, but the mechanisms involved are still unclear. Drawing on the Interpersonal Theory of Suicide, the Evolutionary Model of Loneliness, and Prospect Theory, we examined if high and low levels of loneliness are associated with different patterns of response to losses or gains of belongingness.Methods: A sample of 188 students completed the UCLA-Loneliness scale (version 3) and measures of suicide risk. Participants in the top and bottom tertiles of loneliness scores completed a computerized task designed to induce changes (gains, losses) or consistency in risk factors for suicide (belongingness, burdensomeness) over time, and examined the effect on desire to quit the task. Results:The results showed that the high loneliness group exhibited a larger magnitude of effect on desire to quit from gaining belongingness than for losing belongingness. In contrast, the low loneliness group showed a larger change in desire to quit from losing belongingness than gaining belongingness. Conclusion:The findings provide preliminary experimental support for distinct profiles of suicide risk based on prevailing levels of loneliness. The findings are discussed in relation to a need for increased precision in theoretical models of suicide and loneliness.

Aims: Loneliness has an adverse impact on mental health, yet it is often overlooked in psychological services. To inform clinical practice, we provide an overview of research hotspots on loneliness and mental health, the ‘state of the art’ in assessment and treatment, and workforce implications. Methods: Narrative synthesis. Results: Loneliness occurs in all age groups, with peaks in younger and older adults. It is a well-established risk factor for mental ill-health, neurodevelopmental and neurodegenerative disorders, and other problems prompting people to seek psychological care. A variety of psychometrically sound self-report measures are available for assessment purposes, though some lack structural or cross-cultural validity. The most promising interventions use cognitive-behavioural therapy to change maladaptive social cognitions. Recent studies are focused on identifying mechanisms of change, the role of social networks, and the use of digital technologies to augment treatment. The stigma of loneliness can prevent clients and healthcare professionals from talking openly about it, but the best strategies for combating loneliness stigma are unclear. Conclusion: Loneliness and mental ill-health are mutually reinforcing; hence, loneliness should be routinely considered in clinical practice. Psychological interventions are moderately effective at alleviating loneliness but further research and practice-based evaluation of solutions for loneliness is needed.