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Acute kidney injury (AKI) is a global health challenge of vast proportions, as approx. 13.3% of people worldwide are affected annually. The pathophysiology of AKI is very complex, but its main causes are sepsis, ischemia, and nephrotoxicity. Nephrotoxicity is mainly associated with the use of drugs. Drug-induced AKI accounts for 19–26% of all hospitalized cases. Drug-induced nephrotoxicity develops according to one of the three mechanisms: (1) proximal tubular injury and acute tubular necrosis (ATN) (a dose-dependent mechanism), where the cause is related to apical contact with drugs or their metabolites, the transport of drugs and their metabolites from the apical surface, and the secretion of drugs from the basolateral surface into the tubular lumen; (2) tubular obstruction by crystals or casts containing drugs and their metabolites (a dose-dependent mechanism); (3) interstitial nephritis induced by drugs and their metabolites (a dose-independent mechanism). In this article, the mechanisms of the individual types of injury will be described. Specific groups of drugs will be linked to specific injuries. Additionally, the risk factors for the development of AKI and the methods for preventing and/or treating the condition will be discussed.

BackgroundAbuse against women in labor starts with subtle forms of discrimination that can turn into overt violence. Therefore it is crucial to work towards prevention and elimination of disrespect and ill-treatment in medical facility perinatal care in which staff allows such abuse.The aim of the study was to analyze the experiences of women related to perinatal care. Special emphasis was put on experiences that had traits indicating disrespectful and offensive care during childbirth in medical facilities providing perinatal care.MethodsThis was a cross-sectional survey. A questionnaire was prepared for respondents who gave birth in medical facilities. Information about the study was posted on the website of a non-governmental foundation dealing with projects aimed at improving perinatal care. The respondents gave online consent for processing the submitted data. 8378 questionnaires were submitted. The study was carried out between February 06 and March 20, 2018. The results were analyzed using the Chi-square independence test. The analysis was carried out at the significance level of 0.05 in Excel, R and SPSS.ResultsDuring their hospital stay, 81% of women in the study experienced violence or abuse from medical staff on at least one occasion. The most common abuse was having medical procedures without prior consent. Inappropriate comments made by staff related to their own or a woman’s situation were reported in 25% of situations, whilst 20% of women experienced nonchalant treatment. In the study 19.3% of women reported that the staff did not properly care for their intimacy and 1.7% of the respondents said that the worst treatment was related to feeling anonymous in the hospital.ConclusionsThe study shows that during Polish perinatal care women experience disrespectful and abusive care. Most abuse and disrespect involved violation of the right to privacy, the right to information, the right to equal treatment, and the right to freedom from violence. The low awareness of abuses and complaints reported in the study may result from women’s ignorance about relevant laws related to human rights.

841 Why we should not stop giving aspirin to pregnant women during the COVID-19 pandemicDuring the current coronavirus disease 2019 (COVID-19) pandemic, several questions have arisen relating to the management of pregnant women. The risk of COVID-19 to pregnant women may be much lower than in the previous SARS epidemic. The case fatality rates (CFR) in pregnant women during the SARS and MERS epidemics were 15% and 27%, respectively 1,2 , while

Objectives: Cesarean section is a lifesaving procedure with short and long-term consequences. Growing rates of cesarean sections worldwide arise problems for subsequent birth. The aim of this study was to compare safety of vaginal birth after two cesarean sections with repeat third cesarean section to help healthcare providers and patients make well informed decisions about mode of subsequent delivery. Material and methods: This was a retrospective cohort study conducted in a tertiary reference hospital. Database of all deliveries (2010-2017) after two previous cesarean sections was created from electronic and paper medical records. Preterm deliveries, abnormal karyotype and neonates with congenital anomalies were excluded from the study. The final analysis included 412 cases for maternal outcome analysis and 406 cases for neonatal outcome analysis. Results: Trial of labor after two cesareans in comparison to repeat cesarean section increases the risk of hemorrhage (OR: 10.84) and unfavorable composite maternal outcome (OR: 2.58). Failed trial of labor increases this risk of hemorrhage (OR: 15.27) and unfavorable composite maternal outcome (OR: 4.59) even further. There were no significant differences in neonatal outcomes. 22 out of 35 trials of labor ended in successful delivery giving a success rate of 62.85%. 5 of 7 labor inductions ended in repeat cesarean section giving 28.6% success rate. There were no maternal deaths and emergency hysterectomies. conclusions: Trial of labor, especially failed trial of labor, is associated with an increased risk of perinatal complications.