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Results showed that the lipopeptides were promising agents as the time of the culture did not greatly affect their activity.

Background:The mechanisms of insect immune peptide recognition and evasion by T. cruzi are unknown. Results: Secreted parasite cyclophilin neutralizes lytic peptide, causes activation of parasite calcineurin, and enhances parasite infection. Conclusion: Cyclophilin is a key mediator of antimicrobial peptide evasion and triggers parasite calcineurin signaling. Significance: The cyclophilin-calcineurin pathway is an extracellular peptide microbial-host sensing mechanism.

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