The last three decades of research into tick salivary components have revealed several proteins with important pharmacological and immunological activities. Two primary interests have driven research into tick salivary secretions: the search for suitable pathogen transmission blocking or "anti-tick" vaccine candidates and the search for novel therapeutics derived from tick salivary components. Intensive basic research in the field of tick salivary gland transcriptomics and proteomics has identified several major protein families that play important roles in tick feeding and overcoming vertebrate antitick responses. Moreover, these families contain members with unrealized therapeutic potential. Here we review the major tick salivary protein families exploitable in medical applications such as immunomodulation, inhibition of hemostasis and inflammation. Moreover, we discuss the potential, opportunities, and challenges in searching for novel tick-derived drugs.

This article documents an attempt to translate one chapter of a novel Die Dämonen by Heimito von Doderers from Early New High German into Czech. In its first and main part, it describes how the author treated this historical language, the means he used and to what purpose, and also, the method that would be chosen for its translation into Czech. The second part of the article deals with the sensory perception in this particular passage and how the individual senses are communicated to the reader.