AbstractBrain iron deposits have been reported consistently in imaging and histologic examinations of patients with neurodegenerative disorders. While the origins of this finding have not been clarified yet, it is speculated that impaired iron homeostasis or deficient transport mechanisms result in the accumulation of this highly toxic metal ultimately leading to formation of reactive oxygen species and cell death. On the other hand, there are also those who support that iron is just an incidental finding, a by product of neuronal loss. A literature review has been performed in order to present the key findings in support of the iron hypothesis of neurodegeneration, as well as to identify conditions causing or resulting from iron overload and compare and contrast their features with the most prominent neurodegenerative disorders. There is an abundance of experimental and observational findings in support of the hypothesis in question; however, as neurodegeneration is a rare incident of commonly encountered iron-associated disorders of the nervous system, and this metal is found in non-neurodegenerative disorders as well, it is possible that iron is the result or even an incidental finding in neurodegeneration. Understanding the underlying processes of iron metabolism in the brain and particularly its release during cell damage is expected to provide a deeper understanding of the origins of neurodegeneration in the years to come.

The response of three flames with different degrees of premixedness (fully premixed, non-premixed with radial, and non-premixed with axial fuel injection) to acoustic oscillations is studied experimentally. The flames were imaged using OH* chemiluminescence and OH planar laser-induced fluorescence at 5 kHz. In addition to a flame kinematics analysis, the amplitude dependence of the transfer function was calculated. The dominant spatial structures of the heat release and their periodicity were examined using the proper orthogonal decomposition (POD) method. The Non-Premixed system with Radial fuel injection (NPR) showed the highest response to acoustic forcing, followed by the fully premixed and the Non-Premixed system with Axial fuel injection (NPA). In addition, the response of the nonpremixed system with radial fuel injection was greater than that of the fully premixed system for various bulk velocities U, global equivalence ratios φ, forcing amplitudes A, and forcing frequencies f . In the fully premixed system, the heat release modulation was mainly through flame surface area modulation, while in the NPR system, both the flame area and the equivalence ratio modulations were found to be important mechanisms of the heat release oscillations. About 70% of the energy of the total fluctuations in the NPR case was contained in the first four POD modes, a percentage that decreased with overall equivalence ratio, but only this dropped to about 40% for the NPA flame. The frequency spectra of the coefficients of the POD modes exhibited peaks at the forcing frequency, with increasing broadband contributions in higher modes and for the NPA flame.ARTICLE HISTORY

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The response of swirl non-premixed flames to air flow oscillations is studied using Large-Eddy Simulation (LES) and the Conditional Moment Closure (CMC) combustion model, focusing on the physical mechanisms leading to the heat release rate oscillations observed in a parallel experimental study. Cases relatively close to blow-off and characterized by different amplitude of the flow oscillations are considered. Numerical results are in good agreement with the experiment in terms of both mean flame shape and heat release rate response. Simulations show that the oscillation of the air flow leads to an axial movement and fragmentation of the flame that are more pronounced with increasing amplitude of the forcing. The flame response is characterized by fluctuations of the flame area, time-varying local extinction and lift-off from the fuel injection point. LES-CMC, due to the inherent capability to capture burning state transitions, predicts properly the flame transfer function as a function of the amplitude of the air flow oscillations. This suggests that the response mechanism for this flame is not only due to time-varying flame area, but also local extinction and re-ignition. This study demonstrates that LES-CMC is a useful tool for the analysis of the response of flames of technical interest to large velocity oscillations and for the prediction of the flame transfer function in conditions close to blow-off.

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