The Millon Clinical Multiaxial Inventory (MCMI) was administered to 270 adult outpatients with major affective disorders at the same time that a semistructured, diagnostic interview was conducted by a clinician. The mood of the patient was then rated, and the clinician completed the Hamilton Depression Rating Scale and the Mania Rating Scale. A consensual diagnosis was arrived at by the team of investigators using DSM-III criteria. Significant correlations were found between four MCMI affective scales and the global mood state of the patient. Analysis of covariance indicated that the MCMI affective scales are significantly related to DSM-III affective disorders even after the effect of the current mood of the patient is partialled out. The clinical usefulness of each of the scales is discussed.

SUMMARY A population-based survey of 134 white men, recruited from the Chicago People's Gas Company labor force, was carried out to examine the association between sodium-lithium (Na-Li) countertransport and hypertension. Of the 134 participants in this industry-sponsored periodic health examination, 64 were normotensive and 70 were either taking antihypertensive medications or had a systolic pressure 3= 140 or a diastolic pressure 2= 90 mm Hg. The hypertensives were older and more overweight. Countertransport was significantly higher in hypertensives than in normotensives. Among the three subgroups of hypertensives -untreated borderline (140/90 to 160/95 mm Hg), untreated definite (over 160/95 mm Hg), and treated -an increase in countertransport was consistently observed, significant for the latter two groups. The relationship between countertransport and hypertension was independent of overweight, with countertransport being significantly related to both blood pressure and overweight. Altered ion transport may play an important role in the etiology and/or pathophysiology of hypertension. (Hypertension 5:363-367, 1983) KEY WORDS • countertransport • sodium metabolism • blood pressure R ED blood cell sodium-dependent membrane processes are currently being studied in relation to the etiology and pathogenesis of hypertension. 1 " 14 Previous case control studies have demonstrated a relationship between sodium-lithium (Na-Li) countertransport and hypertension.'-7 -15~17 This report described the results of a populationbased cross-sectional survey in employed white men relating levels of countertransport to the presence of hypertension. Methods Data CollectionVolunteers for this study were male employees (the great majority of whom were white) of the Chicago People's Gas Company participating in the companysponsored periodic health examination. The participation rate in this examination is over 90%. l8 During the period from June 1981 to December 1981, on a semi weekly basis, without selection the first four employees who presented at the company medical office for their regularly scheduled examination were invited to participate; response rate was 100%.A nurse measured blood pressure after the man had rested quietly in the sitting position for 5 minutes. Korotkoff sounds phases I and V were recorded from a single reading with a standard mercury sphygmomanometer. While blood was being sampled for routine laboratory analyses, an additional 15 cc of venous blood was collected in plastic tubes containing ammonium heparin. Samples were collected in the fasting state before 10 a.m. With the man in indoor clothes, with shoes off, height and weight were measured on a balance scale. Medical history was obtained through the use of a self-administered questionnaire.Of 157 white men participating in the study, 21 were excluded from this report because of a major illness (renal, hormonal, psychiatric) thought to influence intracellular ion metabolism. 6 l9 -2I In addition, two participants were excluded because of extremely...

To determine the relationships between clinical and brain function in persons with a familial risk for Alzheimer's disease, the authors assessed subjective and objective cognitive abilities, mood state, and cerebral glucose metabolism (using positron emission tomography) in 43 persons with age-associated memory impairment, with and without first-degree relatives with a clinical diagnosis of Alzheimer's disease. Subjective complaints of memory loss, mood state ratings, and objective memory measures were similar in persons with a family history of Alzheimer's disease (n = 29) compared to those without such a history (n = 14). Metabolic ratios in the frontal regions correlated with a decrease in a specific type of subjective memory complaint (mnemonics usage; p < .001) and some mood state ratings. These results indicate that parietal and temporal hypometabolism is not evident in persons with mild age-related memory complaints, even when such subjects have a familial risk for Alzheimer's disease. Moreover, self-reports of mnemonics usage may be sensitive indicators of decreased frontal lobe function. Longitudinal study will determine whether such clinical and metabolic measures will predict eventual disease progression.

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This study was conducted to identify factors related to functional status within a clinical sample of Veterans of Operation Enduring Freedom (OEF) and Operation Iraqi Freedom (OIF) with a history of traumatic brain injury (TBI). Medical chart review was conducted for a consecutive group of OEF/OIF Veterans who were referred for neuropsychological evaluation within a Veterans Affairs Medical Center Polytrauma Program related to history of TBI (n = 57). Level of involvement in occupational and academic activity, presence or absence of housing insecurity, and clinician ratings of overall functioning served as indicators of functional status. Reduced functional status was most strongly related to poorer cognitive function, particularly motor function, processing speed, and executive function. Lower levels of functioning were also related to increased severity of postconcussive symptoms, lower levels of education, and ongoing medication treatment for sleep or psychiatric symptoms. Comprehensive evaluation of cognitive, affective, and behavioral functioning among OEF/OIF Veterans with a history of TBI is likely to provide valuable information to inform rehabilitation strategies and identify potential warning signs for poor postdeployment reintegration. Increased awareness of these factors may aid clinicians in identifying patients at risk for poor outcomes and in more effectively targeting symptoms for intervention.