Introduction: Laser therapy has been used in medicine for many years. One of the most willingly used is the fractional ablative CO2 laser. As a result of its use, the improvement of pigmentation, skin texture and signs of aging are achieved. Laser therapy owes its popularity to its low invasiveness and good, long-lasting effects of the procedure. Despite its important role in aesthetic medicine, we should not forget about its participation in the treatment of scars, often extensive, causing troublesome symptoms to patients, the source of which is not only a defect of a cosmetic nature. Purpose of the work: The purpose of the study is to present mechanism of action, assessment of safety,  effectiveness in the treatment and possible side effects based on a review of scientific literature. Material and methods: The work was based on a review of available medical publications on the use of the fractional ablative CO2 laser. The literature in the PubMed and Google Scholar databases was searched based on the following keywords: fractional ablative CO2 laser, mechanism of action, safety of use, side effects. Conclusion: The use of a fractional ablative CO2 laser causes the increased collagen production in the dermis. This effect contributes to the elevation of the quantity and level of collagen arrangement, and also to the reduction of the visibility of the effects of photoaging. As a result, the skin in the treated area becomes thicker, and thus firmer. The pigmentation and texture are also being improved. The procedure is relatively slightly invasive, and the side effects are self-limiting in the most cases.

Introduction: The disease caused by SARS-CoV-2 is associated with a dysregulated immune response and a generalized inflammatory response. Therefore, during the search for effective therapy, attention was paid to drugs affecting and stabilizing such a response - tocilizumab, sarilumab, siltuximab, anakinra, baricitinib.Purpose of the work: Evaluation of the impact of immunosuppressant therapy on the course of the disease caused by the SARS-CoV-2 virus.Material and methods: The work was based on a review of available medical publications about immunosuppressive therapy for COVID-19 treatment. The literature in the PubMed and Google Scholar databases was searched based on the following keywords: tocilizumab, sarilumab, siltuximab, baricitinib, COVID-19, SARS-CoV-2, immunosuppressive therapy.Conclusion: Based on the analysis of the literature, the most effective therapeutic option seems to be tocilizumab. Promising alternatives may be sarilumab and siltuximab as they have the same target point of action. However, it is necessary to conduct further tests on their operation. The use of baricitinib may be useful, but probably only in certain circumstances. Anakinra proved to be much less effective. It should therefore be used with great caution.

Inflammatory bowel diseases are increasingly common problem in clinical practice. This condition is caused by both the growing morbidity and more accurate and widely available diagnostic methods, affecting the rising recognition.  It is worth remembering, that clinical presentation of inflammatory bowel disease is not limited to gastrointestinal tract.  Dermatological symptoms are an important part in the diagnosis of inflammatory bowel diseases, because they can occur as the first manifestation of the beginning of the disease process, as well as be a prognostic factor for the occurrence of exacerbations of the disease. This is an invaluable source of information on the patient's clinical condition, affecting the effectiveness of his treatment in the early stages of the disease, and allowing more efficient control of its course.  This has an enormous impact on the prognosis and comfort of patients' lives. In the following article, available medical studies on extraintestinal skin manifestations, clinical presentation and treatment options have been reviewed.

INTRODUCTION. Acute appendicitis is the most common reason for abdominal surgery in children however in newborn and infants it’s casuistics. It is also the most common surgical emergency in pregnancy. Right lower abdominal pain, abdominal stiffness, and periabdominal pain radiating to the right lower abdomen are the best signs to diagnose acute appendicitis in adults. Absence Or attenuation of intestinal murmurs, positive sternal muscle signs, positive blunt signs, and positive Rovsing's Sign are the most reliable signs for the diagnosis of acute appendicitis in children. PURPOSE. The aim of the study is to show diagnostic difficulties of acute appendicitis in newborns and infants. It is one of the main differential diagnoses of unclear abdominal conditions. The smaller the child, the less characteristic the symptoms. A CASE REPORT. The study analyzes a male newborn born in the 37th week of pregnancy by caesarean section. Prenatal and family history of siblings' illnesses. In whom, on the 11th day of life, symptoms of food intolerance were found, green deposits were noticed in the stomach probe, and the presence of blood in the stool. Intraoperatively, gangrenous perforated appendix with diffuse peritonitis was found.Acute appendicitis is rarely considered in newborns and infants as the etiological factor of acute peritonitis. However, the presented patient with a genetic defect.CONCLUSION. Acute appendicitis is a common phenomenon in childhood, but this diagnosis is rarely considered in the differential diagnosis of acute abdomen in the neonatal period, is more common in premature babies. The clinical picture of neonatal acute appendicitis is unspecific and may lead to delayed diagnosis and misdiagnosis of necrotizing enterocolitis, which is a much more common condition in the neonatal period. We would like to present the diagnostic difficulties, course of treatment, and complications associated with neonatal appendicitis.

Introduction The term gender dysphoria has been known to humanity for a long time. Transsexuality has many definitions, but each of them leads to the same conclusions. It is a lack of acceptance of one's own biological sex, the one indicated by the anatomy and sex given to a newborn human. For these people, it is important that their appearance and tone of voice allow them to be recognized according to the gender they want to represent. This topic requires a multidisciplinary approach of specialists from various fields of medicine, such as: phoniatrics, otolaryngology, endocrinology, surgery and psychiatry. Purpose The aim of study is to review data on voice modification in both transgender men and transgender women. The possibilities that medicine offers to people who want to change the tone, quality and pitch of their voice will be emphasized. MethodsA systematic review and meta-analysis of the literature was performed using the PubMed, Cochrane, Embase, Medline, and Science Direct databases. ResultsChanging the voice of transgender people is essential for self-acceptance and improves the quality of life of such people. Mental health problems such as depression and anxiety have been found to be significantly less after treatment has been implemented in these people's lives. ConclusionsMedicine offers many solutions, from conservative to invasive. Over the years, therapies have been developed that combine many medical fields, and these often bring the expected results. People who decide to undergo surgery must be aware that the results may not always be as expected or that complications may occur.