Carboxylic acid-functionalized Pd and Pt PNP pincer complexes were used for the assembly of two porous Zr metal-organic frameworks (MOFs), 2-PdX and 2-PtX. Powder X-ray diffraction analysis shows that the new MOFs adopt cubic framework structures similar to the previously reported ZrO(OH)[(PCP)PdX], [PCP = 2,6-(OPAr)CH); Ar = p-CHCO, X = Cl, I] (1-PdX). Elemental analysis and spectroscopic characterization indicate the presence of missing linker defects, and 2-PdX and 2-PtX were formulated as ZrO(OH)(OAc)[M(PNP)X] [M = Pd, Pt; PNP = 2,6-(HNPAr)CHN; Ar = p-CHCO; X = Cl, I]. Postsynthetic halide ligand exchange reactions were carried out by treating 2-PdX with Ag(OSCF) or NaI followed by PhI(OCCF). The latter strategy proved to be more effective at activating the MOF for the catalytic intramolecular hydroamination of an o-substituted alkynyl aniline, underscoring the advantage of using halide exchange reagents that produce soluble byproducts.

The results of this study suggest that Meretoja syndrome causes corneal nerve damage and eventual degeneration that correlates with the degree of clinical involvement.