Adjuvant treatment with docetaxel, as compared with vinorelbine, improves recurrence-free survival in women with early breast cancer. A short course of trastuzumab administered concomitantly with docetaxel or vinorelbine is effective in women with breast cancer who have an amplified HER2/neu gene. (International Standard Randomised Controlled Trial number, ISRCTN76560285.).

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Technical lignins are structurally heterogeneous and polydisperse. This work describes the use of a simple and green method for lignin fractionation, using different proportions of acetone (40 and 60%) in water. Lignins from three different sources (wheat straw organosolv lignin, wheat straw soda lignin and softwood kraft lignin) were used in this fractionation protocol. The obtained fractions showed different molar mass and functional groups. The lower molar mass fractions showed more phenolic hydroxyl groups and carboxylic acid moieties than higher molar mass fractions, which also possessed much higher amounts of carbohydrates. The chemical characterization of these fractionated lignins showed that the PREC fraction was exceptionally pure and homogeneous lignin. Its total lignin content was >96% for all three lignins and it was practically free from carbohydrates and inorganics (ash). Furthermore, PREC fraction possessed the highest carbon content for the three lignin samples (63.05-69.26%). These results illustrate that the proposed aqueous acetone fractionation protocol could indeed produce pure and uniform lignin fraction and it was applicable for lignins from different sources.

The QoL of the patients shortly after adjuvant treatments was impaired and the physical performance poor as compared to general population. In particular, depression and fatigue were related to impaired QoL. Physical performance and activity level were the only factors that correlated positively to QoL. Thus, physical exercise could be useful in rehabilitation of cancer survivors, especially for depressed and fatigued patients.

This 12-month aerobic jumping and circuit training intervention completely prevented femoral neck bone loss in premenopausal breast cancer patients, whereas no effect on BMD was seen in postmenopausal women.