This study aimed to examine the efficacy and maintenance of short-term (one-session) gated audiovisual speech training for improving auditory sentence identification in noise in experienced elderly hearing-aid users. Twenty-five hearing aid users (16 men and 9 women), with an average age of 70.8 years, were randomly divided into an experimental (audiovisual training, n = 14) and a control (auditory training, n = 11) group. Participants underwent gated speech identification tasks comprising Swedish consonants and words presented at 65 dB sound pressure level with a 0 dB signal-to-noise ratio (steady-state broadband noise), in audiovisual or auditory-only training conditions. The Hearing-in-Noise Test was employed to measure participants’ auditory sentence identification in noise before the training (pre-test), promptly after training (post-test), and 1 month after training (one-month follow-up). The results showed that audiovisual training improved auditory sentence identification in noise promptly after the training (post-test vs. pre-test scores); furthermore, this improvement was maintained 1 month after the training (one-month follow-up vs. pre-test scores). Such improvement was not observed in the control group, neither promptly after the training nor at the one-month follow-up. However, no significant between-groups difference nor an interaction between groups and session was observed. Conclusion: Audiovisual training may be considered in aural rehabilitation of hearing aid users to improve listening capabilities in noisy conditions. However, the lack of a significant between-groups effect (audiovisual vs. auditory) or an interaction between group and session calls for further research.
Longitudinal serum samples, nasopharyngeal/nasal swabs and rectal swab samples were collected from eighty-nine individuals (median age 66 y) with SARS-CoV-2 PCR-positive test results at Linköping University Hospital. Samples were collected from the initial visit and thereafter for up to 2 years of follow-up. The presence of serum IgG and IgA against SARS-CoV-2 antigens (S1-spike, nucleocapsid, and NSP3) was analysed. Nasal and rectal swabs were tested for the presence of mucosal IgA against the outer envelope S1 spike and the nucleocapsid protein. Ninety percent of the participants were seropositive for SARS-CoV-2 recombinant proteins on Day 28 after study entry, and all (100%) were seropositive based on samples collected 2 months or later. Almost all (95%) developed serum SARS-CoV-2-neutralizing antibodies that were measurable from 6 to 24 months. The most common antibody responses (both serum IgG, mainly IgG1, and in nasal mucosa IgA) reacted with the S1-spike protein and the nucleoprotein. In samples collected from nasal tissues, IgA anti-S1 spike protein was mainly observed during 2 months of follow-up. In a subpopulation (18% of tested individuals), rectal IgA swabs showed the presence of anti-S1 spike IgA for 1 month of follow-up among the participants studied. .
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