Journal of Liquid ChromatographyPublication details, including instructions for authors and subscription information: ABSTRACT A simple reverse-phase high performance l i q u i d chroma tographic method i s evaluated f o r the estimation of octanol-water p a r t i t i o n c o e f f i c i e n t s ( l o g P) of organic compounds by c o r r e l a t i o n with t h e i r chromatographic capacity f a c t o r s (k' ). Using an unmodified commercial octadecylsilane column and a mobile phase c o n s i s t i n g of methanol and an aqueous b u f f e r , a l i n e a r r e l a t i o n s h i p i s e s t a b l i s h e d between the l i t e r a t u r e log P values of 68 compounds and the logarithms of t h e i r k ' values. the p a r t i t i o n c o e f f i c i e n t s of unknowns, one of two s e t s of standards i s used t o c a l i b r a t e the system, the choice being dependent on the hydrogen-bonding c h a r a c t e r of the compounds being evaluated. The o v e r a l l method i s shown t o be rapid and widely adaptable and t o give log P d a t a which a r e comparable t o r e s u l t s obtained by c l a s s i c a l o r o t h e r c o r r e l a t i o n methods.

Nucleic acid amplification tests (NAATs), which amplify and detect pathogen nucleic acids, are vital methods to diagnose diseases, particularly in cases where patients exhibit low levels of infection. For many...

A liquid phase microextraction method using hollow fiber to support extraction solvent was developed for enrichment of trace level chloroanilines in environmental water samples. Target analytes, 2-chloroaniline, 3-chloroaniline, 2,3-dichloroaniline, 2,4-dichloroaniline, 3,4-dichloroaniline, and 3,5-dichloroaniline were determined using gas chromatography-flame ionization detector after extraction. Experimental conditions that affect extraction efficiency were investigated and optimized. The proposed method showed a wide linear range from lower lg L -1 to 1,000 lg L -1 , low detection limits (B5.1 lg L -1 ), and reasonable relative standard deviations (RSDs \ 13%). Feasibility of the method was evaluated by analyzing river water samples collected from the Hudson River and the East River in New York City.