Trailing edge blowing over a Coanda surface has been utilised as a circulation control mechanism for increasing the lift of an aircraft wing. Typically, high energy air is blown from a narrow spanwise slot over the rounded trailing edge of a wing and the air supply is modulated to effect a degree of lift control on the wing. This configuration produces an aerodynamic force in a uni-directional sense only. An alternative novel flow control actuator is described which utilises a simple variable geometry Coanda surface with upper and lower spanwise blowing slots to achieve fully proportional bi-directional control in the manner of a conventional flap. A prototype device has been wind-tunnel tested and is shown to have substantially linear response characteristics and to be as efficient as an equivalent flap surface. The performance of a flow control actuator suitable for small UAV applications is described.

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A computational investigation of the interaction of the vectored primary jet from the main engine with the subsonic flow around a tailless unmanned air vehicle (UAV) configuration, with a cropped diamond wing planform, has been carried out. An initial study has been completed using Reynolds-averaged Navier-Stokes methods in conjunction with the shear-stress transport k-ω model. Various sets of simulations were performed on the basis of quantifying the thrust vectoring (TV) jet entrainment effects by means of aerodynamic forces and moments when key factors are combined, such as angles of thrust velocity deflection at different jet Mach number and angles of attack. It was found that reaction forces induced by the modified pressure on the integrated boundary of the body results in an enhancement of the TV effectiveness in producing the forces and moments required for the flight vehicle trim and manoeuvring. Those reaction forces were found to be independent of the angle of attack.

Commonly found colonizing the human microbiota, Candida albicans is a microorganism known for its ability to cause infections, mainly in the vulvovaginal region, and is responsible for 85% to 90% of vulvovaginal candidiasis (VVC) cases. The development of drug resistance in C. albicans isolates after long-term therapy with fluconazole is an important complication to solve and new therapeutic strategies are required to target this organism and its pathogenicity. In the present study, phenyllactic acid (PLA) an important broad-spectrum antimicrobial compound was investigated for its antifungal and antivirulence activities against clinical isolates of C. albicans. Previously characterized strains of C. albicans isolates from women with VVC and C. albicans ATCC90028 were used to evaluate the antimicrobial and time dependent killing assay activity of PLA showing a MIC 7.5 mg mL−1 and a complete reduction of viable Candida cells detected by killing kinetics after 4 h of treatment with PLA. Additionally, PLA significantly reduced the biomass and the metabolic activity of C. albicans biofilms and impaired biofilm formation also with changes in ERG11, ALS3, and HWP1 genes expression as detected by qPCR. PLA eradicated pre-formed biofilms as showed also with confocal laser scanning microscopy (CLSM) observations. Furthermore, the compound prolonged the survival rate of Galleria mellonella infected by C. albicans isolates. These results indicate that PLA is a promising candidate as novel and safe antifungal agents for the treatment of vulvovaginal candidiasis.

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