Background: Nurses perform many actions during the therapy process. However, the time dedicated to the process of drug therapy is very important for the children’s safety; indeed, assessing the factors that can impact on the whole therapy process represent an important objective.  Aim. The primary aim of this scoping review is to investigate the factors associated to the interruptions of the therapeutic process (i.e., preparation, administration and, monitoring) for inpatient paediatric population. The secondary aim is to investigate possible implementation strategies to prevent interruptions and, thus, prevent medical administration error (MAE).  Materials and method: A scoping review was performed, following the PRISMA guidelines using the keywords ‘paediatric’ AND ‘interruption to therapy administration/preparation/ monitoring’. The search was performed during April 2022.  Results: Out of 242 records retrieved, 8 full text studies met the inclusion criteria and therefore, included in the review. the included full texts were grouped according to the stage of the therapy process they addressed. The majority of the studies adopted an observational design and highlighted how interruptions can occur due to environmental reasons and people. All the included studies focused on the “negative” consequences of interruptions, although, they reveal that the nurses constitute a resilient profession, because they can implement adaptive strategies in extremely disruptive environments and organizations. However, development of new strategies to reduce interruptions during the therapy process is highly needed to guarantee the safety of the children.  Conclusion: we recognize that prioritization is an ongoing challenge, indeed the first step is a cultural change in order to implement new organizational and clinical models where “positive” disruptions are allowed and the “negative” ones are blocked or prevented.