Earlier detection and classification of squamous cell carcinoma (OSCC) is a widespread issue for efficient treatment, enhancing survival rate, and reducing the death rate. Thus, it becomes necessary to design effective diagnosis models for assisting pathologists in the OSCC examination process. In recent times, deep learning (DL) models have exhibited considerable improvement in the design of effective computer-aided diagnosis models for OSCC using histopathological images. In this view, this paper develops a novel duck pack optimization with deep transfer learning enabled oral squamous cell carcinoma classification (DPODTL-OSC3) model using histopathological images. The goal of the DPODTL-OSC3 model is to improve the classifier outcomes of OSCC using histopathological images into normal and cancerous class labels. Finally, the variational autoencoder (VAE) model is utilized for the detection and classification of OSCC. The performance validation and comparative result analysis for the DPODTL-OSC3 model are tested using a histopathological imaging database.
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