For Malignant Melanoma (MM), the Breslow thickness and the presence of ulceration are important elements for determining the staging and prognosis 1 . Skin cancer screening and dermoscopic examination allowed an earlier recognition of cutaneous MM, causing especially an over‐detection of thin lesions, without a proportional decline in later‐stage disease 2 . Furthermore, the incidence of thicker MMs does not seem to be decreasing 3;4 .

Background. Sex and gender may affect disease prevalence, adverse effects and response to therapy. Aim. To analyse sex and gender differences in outpatients with psoriasis. Methods. A cross-sectional study was conducted at IDI-IRCCS, Rome, over a 3-year period. In total, 3023 patients with psoriasis were enrolled. Anthropometric and demographic characteristics were recorded, and a dermatologist evaluated the clinical severity of disease. Quality of life (QoL) questionnaires were collected. Univariate and multivariate analyses were performed to examine factors associated with sex. Results. We found sex-and gender-associated differences in clinical characteristics, disease severity, psychological distress and quality of life. Male sex was associated with body mass index, smoking, alcohol consumption, Psoriasis Area Severity Index ≥ 10 and age at onset ≥ 20 years. Female sex was associated with family history of diabetes, joint involvement, clinical type other than diffuse plaque psoriasis, higher psychological distress and a greater effect on QoL. Conclusion.Our study identified sex and gender differences of potential clinical relevance in psoriasis.

MMF use does not appear to be associated with an significantly increased risk of infection occurring after liver transplantation and is associated with fewer episodes of acute rejection.

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Background/Aim: Hidradenitis suppurativa (HS) is a chronic skin disease with a heavy impact on patients’ quality of life (QoL). The aim of this study was to evaluate in detail the QoL impact of HS comparing it with other skin conditions, and in particular with psoriasis. Methods: Patients with a diagnosis of HS were recruited. QoL was measured using the Skindex-17 questionnaire. Results: Data were available for 69 HS patients. HS had the worst QoL among several skin conditions. Compared to psoriasis the mean symptom score was 69.4 versus 53.7, and the mean psychosocial score was 56.1 versus 32.7. Overall, the scores of patients with HS were higher than those of psoriasis patients on 16 of the 17 items of the Skindex-17. Conclusions: When compared to many different skin conditions, and in particular to psoriasis, HS was the most impairing condition, even at low levels of clinical severity.