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Key indicatorsSingle-crystal X-ray study T = 293 K Mean '(C±C) = 0.003 A Ê R factor = 0.045 wR factor = 0.135 Data-to-parameter ratio = 14.3For details of how these key indicators were automatically derived from the article, see

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Some ways to use the N‐acyl iminium salt methodologies to synthesize a new inhibitor of tubulin polymerization, methyl N‐(3,4,4′,5‐tetramethoxybenzhydryl)pyroglutamate (HEI 81) were studied. The most interesting reactions utilize a new pyroglutamic lactone (3‐(3,4,5‐trimethoxyphenyl)dihydropy‐rrolo[1,2‐c]oxazole‐1,5‐dione).