Giant cell arteritis (GCA) is the most common large vessel vasculitis in the elderly population. In recent years, advanced imaging has changed the way GCA can be diagnosed in many locations. The GCA fast-track clinic (FTC) approach combined with ultrasound (US) examination allows prompt treatment and diagnosis with high certainty. FTCs have been shown to improve prognosis while being cost effective. However, all diagnostic modalities are highly operator dependent, and in many locations expertise in advanced imaging may not be available. In this paper, we review the current evidence on GCA diagnostics and propose a simple algorithm for diagnosing GCA for use by rheumatologists not working in specialist centres.

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Objectives To compare limited, to a more extended ultrasound examination (anteromedial ultrasound, A2-ultrasound) to detect large vessels (LV) involvement in patients with newly diagnosed giant cell arteritis (GCA). Methods Patients with new-onset GCA were included at the time of diagnosis. All patients were examined using limited ultrasound (ultrasound of the axillary artery as visualized in the axilla), and extended A2-ultrasound method (which also includes the carotid, vertebral, subclavian, and proximal axillary arteries), in addition to the temporal artery ultrasound. Results One hundred and thirty-three patients were included in the study. All patients fulfilled the criteria according to a proposed extension of the 1990 American College of Rheumatology (ACR) classification criteria for GCA and had a positive ultrasound examination at diagnosis. Ninety-three of the 133 GCA patients (70,0%) had LV involvement when examined by extended A2-ultrasound, compared with only 56 patients (42,1%) by limited ultrasound (p< 0,001). Twelve patients (9.0%) had vasculitis of the vertebral arteries as the only LV involved. Five patients (3,8%) would have been missed as having GCA if only limited ultrasound was performed. Forty patients (30,0%) had isolated cranial GCA (c-GCA), 21 patients (15,8%) had isolated large vessel GCA (LV-GCA), and 72 patients (54,1%) had mixed-GCA. Conclusion Extended A2-ultrasound examination, identified more patients with LV involvement than limited ultrasound method. However, extended A2-ultrasound requires high expertise and high-end equipment and should be performed by ultrasonographers with adequate training.

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