Advanced prostate cancer initially responds to hormonal treatment, but ultimately becomes resistant and requires more potent therapies. One mechanism of resistance observed in around 10–20% of these patients is lineage plasticity, which manifests in a partial or complete small cell or neuroendocrine prostate cancer (NEPC) phenotype. Here, we investigate the role of the mammalian SWI/SNF (mSWI/SNF) chromatin remodeling complex in NEPC. Using large patient datasets, patient-derived organoids and cancer cell lines, we identify mSWI/SNF subunits that are deregulated in NEPC and demonstrate that SMARCA4 (BRG1) overexpression is associated with aggressive disease. We also show that SWI/SNF complexes interact with different lineage-specific factors in NEPC compared to prostate adenocarcinoma. These data point to a role for mSWI/SNF complexes in therapy-related lineage plasticity, which may also be relevant for other solid tumors.

Magnetic frustration and low dimensionality can prevent long range magnetic order and lead to exotic correlated ground states. SrDy 2 O 4 consists of magnetic Dy 3+ ions forming magnetically frustrated zig-zag chains along the c-axis and shows no long range order to temperatures as low as T = 60 mK. We carried out neutron scattering and AC magnetic susceptibility measurements using powder and single crystals of SrDy 2 O 4 . Diffuse neutron scattering indicates strong one-dimensional (1D) magnetic correlations along the chain direction that can be qualitatively accounted for by the axial next-nearest neighbour Ising (ANNNI) model with nearestneighbor and next-nearest-neighbor exchange J 1 = 0.3 meV and J 2 = 0.2 meV, respectively. Three-dimensional (3D) correlations become important below T * ≈ 0.7 K. At T = 60 mK, the short range correlations are characterized by a putative propagation vector k 1/2 = (0,2 ). We argue that the absence of long range order arises from the presence of slowly decaying 1D domain walls that are trapped due to 3D correlations. This stabilizes a low-temperature phase without long range magnetic order, but with well-ordered chain segments separated by slowly-moving domain walls.

We report on the antiferromagnetic exchange coupling between a submonolayer of Mn(II)-phthalocyanine molecules and a ferromagnetic Eu(II)-oxide thin film. The exchange energy is larger by nearly two orders of magnitude compared to previous studies involving oxidic substrates.

Grapevine red blotch is a recently identified viral disease that was first recognized in the Napa Valley of California. Infected plants showed foliar symptoms similar to leafroll, another grapevine viral disease, on vines testing negative for known grapevine leafroll-associated virus. Later, the Grapevine red blotch virus (GRBV) was independently discovered in the US states of California and New York and was demonstrated to be the causal agent of red blotch disease. Due to its wide occurrence in the United States, vector transmission, and impacts on grape industry, this virus has the potential to cause serious economic losses. Despite numerous attempts, it has yet not been possible to isolate or visualize viral particles from GRBV-infected plants, thereby hampering the development of a serological assay that would facilitate GRBV detection in grapevine. In this work, mass spectrometry approaches were applied in order to quantify GRBV in infected plants and identify potential biomarkers for viral infection. We present for the first time the physical detection on the protein level of the two GRBV genes V1 (coat protein) and V2 in grapevine tissue lysates. The GRBV coat protein load in petioles was determined to be in the range of 100–900 million copies per milligram wet weight by using three heavy isotope labeled reference peptides as internal standards. In leaves on the other hand, the V1 copy number per unit wet tissue weight appeared to be about six times lower than in petioles, and about 300 times lower in terms of protein concentration in the extractable protein mass, albeit these estimations could only be made with one reference peptide detectable in leaf extracts. Moreover, we found in leaf and petiole extracts of GRBV-infected plants a consistent upregulation of several enzymes involved in flavonoid biosynthesis by label-free shotgun proteomics, indicating the activation of a defense mechanism against GRBV, a plant response already described for Grapevine leafroll-associated virus infection on the transcriptome level. Finally and importantly, we identified some other microorganisms belonging to the grapevine leaf microbiota, two bacterial species (Novosphingobium sp. Rr 2-17 and Methylobacterium) and one virus, Grapevine rupestris stem pitting-associated virus.

We treat the two-particle Green's function in the Hubbard model using the recently developed τ -CPA, a hybrid treatment that applies the coherent-potential approximation (CPA) up to a time τ related to the inverse of the band width, after which the system is averaged using the virtual-crystal approximation (VCA). This model, with suitable approximations, does predict magnetism for a modified Stoner criterion. The evaluation of the two-particle propagator in the τ -CPA requires the solution of the pure CPA, within whose formalism the vertex correction and the weighted Green's functions are obtained. The dynamical susceptibility, including the vertex correction and the weighted scattering by the residual interaction, is calculated and shows a spin wave spectrum in the ferromagnetic regime.