This study provided a systemic review of the content of 50 behavioral and social science studies investigating enactment and outcomes of anti-Asian stigma related to coronavirus disease (COVID-19) published in the final quarter of 2020 and during 2021. Based on a systematic search of several databases in December of 2021, 500 studies describing the impact of COVID-related stigma on Asian Americans were identified. From this group, 50 studies meeting the inclusion criteria were analyzed focusing on health and social consequences of stigma. The studies were described by five stigma themes: the enactment of stigma, health consequences of stigma, stigma in the social media, Asian American stigma in education, and policy and political consequences of anti-Asian stigma. The studies appeared in a wide range of scholarly journals using several methodologies. While some studies exclusively focused on health impacts of stigma, all considered how Asian Americans have been scapegoated for COVID-19. Spread of blame and digital stigma on the social media has been particularly damaging to psychological well-being. Discussion of these studies provided an informative systemic overview for how scholars from various disciplines have investigated the antecedents and possible mechanisms leading to anti-Asian hate. This study serves as a baseline for other scholars who want to build on this body of research in future studies as Omicron and other potential future variants of COVID unfold.