The recent measurement of helium-4 from the near-infrared spectroscopy of extremely metal-poor galaxies by the Subaru Survey may point to a new puzzle in the Early Universe. We exploit this new helium measurement together with the percent-level determination of primordial deuterium, to assess indications for a non-vanishing lepton asymmetry during the Big Bang Nucleosynthesis (BBN) era, paying particular attention to the role of uncertainties in the nuclear reaction network. A cutting-edge Bayesian analysis of BBN data jointly with information from the Cosmic Microwave Background suggests the existence of a nonzero lepton asymmetry at around the 2σ level, providing a hint for cosmology beyond ΛCDM. We discuss conditions for a large total lepton asymmetry to be consistently realized in the Early Universe.