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Introduction: Dexmedetomidine and propofol are both associated with risk of sinus bradycardia and hypotension. High grade AV block has rarely been reported with these medications. We present a case of high grade AV block (Mobitz II) in the setting of co administration of dexmedetomidine and propofol resulting in hypotension, that resolved with discontinuation of propofol. Case: 85 year old female with history significant for hypertension and CLL was admitted to the ICU with ARDS secondary to COVID-19 requiring mechanical ventilation. Along with management of ARDS, dexmedetomidine and propofol were administered for adequate sedation while trying to limit high dose of propofol. On day one of administration of the combination (16 mcg/kg/min propofol and 0.6 mcg/kg/hr dexmedetomidine), patient developed Mobitz II AV block associated with hypotension with systolic pressure in 60s. Propofol was discontinued and AV block and hypotension resolved. Patient continued to improve and was eventually extubated and transferred to the telemetry floor. Her telemetry during hospital course did not reveal any further high grade AV block and thus patient did not require placement of a pacemaker. Discussion: Optimizing sedation in intubated patients and knowledge of associated adverse effects is warranted to minimize mechanical ventilation time and prevent life threatening complications. Dexmedetomidine has been associated with a reduction in mechanical ventilation duration but an increased risk of bradycardia and hypotension as compared to midazolam and propofol. (1) Hypotension is common with propofol but sinus bradycardia and arrythmias have also been reported. (2) Rarely propofol can precipitate high grade AV block that can be life threatening if not promptly addressed. (3) Co administration of dexmedetomidine and propofol can be associated with exaggeration of individual side effects. Mindfulness of such adverse effects can not only help prevent life threatening complications but also decrease chances of unnecessary pacemaker placements. Conclusion: Propofol though associated with sinus bradycardia, may result in high grade AV block when co-administered with dexmedetomidine that is usually reversible with discontinuation of the offending drug.

INTRODUCTION: Meckel diverticulum(MD), characterized as a common congenital malformation and is well studied in the pediatric population but less so in adults. Our case emphasizes MD as one of the possible diagnoses of gastrointestinal bleeding in adults when CT scans and endoscopic evaluations are unremarkable. Also, if the suspicion is high, the technetium 99m pertechnetate is also not often adequate to exclude the diagnosis.CASE PRESENTATION: 28 year old male with a history of Inflammatory bowel syndrome presented to the emergency department with lightheadedness and palpitations. Soon after, he experienced a large melanotic stool and was transferred to the ICU with hypovolemic shock. His labs were notable for normocytic normochromic anemia for which he was transfused with packed red blood cells. CTA abdomen and pelvis demonstrated no evidence for active extravasation. The patient continued to have massive melenic bowel movements requiring repetitive blood transfusion for his hemorrhagic shock. Bedside double endoscopy showed non-bleeding internal hemorrhoids with no obvious source of bleeding. Subsequently, workup was broadened to a tagged RBC scan which was positive in the mid to distal small bowel prompting small ileal branch embolization. However, bleeding persisted for which Meckel's scan was ordered and found to be suggestive of Meckel's diverticulum. Subsequently, he had a laparoscopic small bowel resection which led to the resolution of symptoms.DISCUSSION: Meckel's Diverticulum is a rare entity in adults with only 17 cases reported in literature in the last year. It usually presents in childhood with more than half of the patients being less than 10 years old.MD usually presents with intestinal obstruction, hemorrhage and inflammation ofthe diverticulum with or without perforation. Bleeding usually occurs from an ulcer due to ectopic gastric mucosa producing acid and damaging the intestinal mucosa. Clinical features are comparable to any other inflammatory condition and can be confused with more prevalent conditions like acute appendicitis. Meckel's nuclear scan proves to be the standard test in case of high suspicion with a sensitivity of 89.6% and specificity of 97.1%. Other testing modalities include X-ray, CT scan or an MRI in case of an obstruction. Mesenteric arteriography in case of GI bleeding, double-balloon enteroscopy or capsule endoscopy can be used in order to directly visualize the MD, or abdominal exploration can be done as required if the diagnosis remains unclear with high index of suspicion.The standard of treatment in case of a symptomatic patient is surgical resection by performing a diverticulectomy that our patient underwent and was discharged to medical floor after stabilization.CONCLUSIONS: Meckel's Diverticulum remains a diagnosis associated with pediatric population although should not be forgotten in cases of adults with unexplained gastrointestinal bleeding.

There has been a global impact by the virus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the relevant disease called coronavirus disease 2019 (COVID-19) that has affected thousands of lives.(1),(2) This case report highlights the uncommon presentation of a patient who tested positive for COVID-19. Around this time, our hospital's incidence of SARS-CoV-2 was 1 positive test result through our drive-through process.(3)