No abstract

Trichomoniasis is caused by the parasitic protozoan Trichomonas vaginalis and is the most prevalent, nonviral sexually transmitted disease. The parasite has shown increasing resistance to the current 5-nitroimidazole therapies indicating the need for new therapies with different mechanisms. T. vaginalis is an obligate parasite that scavenges nucleosides from host cells and then uses salvage pathway enzymes to obtain the nucleobases. The adenosine/guanosine preferring nucleoside ribohydrolase was screened against a 2000-compound diversity fragment library using a 1 H NMR-based activity assay. Three classes of inhibitors with more than five representatives were identified: bis-aryl phenols, amino bicyclic pyrimidines, and aryl acetamides. Among the active fragments were 10 compounds with ligand efficiency values greater than 0.5, including five with IC 50 values <10 μM. Jump-dilution and detergent counter screens validated reversible, targetspecific activity. The data reveals an emerging SAR that is guiding our medicinal chemistry efforts aimed at discovering compounds with nanomolar potency.

No abstract

Lymphangiomas are rare, benign tumors of the lymphatic system. They are formed through congenital malformation leading to lymphangiectasias. Thus, lymphangiomas are mostly seen in children and infants. Lymphangiomas are a benign lesion, therefore, if the patient is asymptomatic and the lesion is stable, complete surgical resection is not required and imaging surveillance is the preferred method of follow-up. This study reports a rare presentation of lymphangioma in the pancreas.

No abstract