Diabetes mellitus tipe 2 disebabkan oleh ekspresi PTP1B yang tinggi dan  mempengaruhi aktivitas PTKs, yang menyebabkan insulin gagal berikatan dengan reseptor insulin dan menginduksi resistensi insulin. Senyawa xanton dan benzofenon merupakan senyawa yang telah diketahui memiliki aktivitas farmakologi sebagai antidiabetes. Salah satu tanaman dengan kandungan senyawa tersebut adalah Garcinia cowa. Penelitian ini dilakukan dengan tujuan untuk mengetahui afinitas dan mekanisme inhibisi PTP1B oleh senyawa turunan xanton, benzofeno, dan triterpenoid dalam Garcinia cowa antara lain garcinia cowone K, guttiferone I, 1,7-dihydroxyxanthone, 1-hydroxyl-7-methoxyxanthone, mangostinone, ?-mangostin, cowanol, gacibiphenyl C, friedelin, ?-friedelinol, dan oleanane-12-ol secara in silico dengan molecular docking serta melakukan studi pre-ADMET terhadap senyawa tersebut. Molecular docking dilakukan melalui beberapa tahap diantaranya preparasi dan optimasi struktur 3D senyawa uji, preparasi struktur 3D reseptor PTP1B, validasi metode, dan docking senyawa uji dengan PTP1B. Hasil yang diperoleh dari docking senyawa uji dengan reseptor PTP1B berupa energi ikatan, konstanta inhibisi (KI), dan ikatan hidrogen. Semakin rendah nilai energi ikatan menunjukkan ikatan antara protein dan ligan yang dihasilkan semakin stabil. Hasil penelitian menunjukkan energi ikatan dan KI PTP1B dengan native ligand berturut-turut sebesar -10,07 kkal/mol dan 0,0417 ?M. Sementara dengan senyawa ?-mangostin berturut-turut sebesar -8,91 kkal/mol dan 0.29317 ?M. Hal tersebut menunjukkan bahwa senyawa ?-mangostin memiliki potensi sebagai antidiabetes mellitus tipe 2 dengan menghambat PTP1B. Selain itu, senyawa ?-mangostin juga memiliki profil ADMET yang baik. Kata kunci:   antidiabetes, diabetes mellitus tipe 2, penambatan molekuler, PTP1B, Xanton           Type 2 diabetes mellitus is caused by high PTP1B expression and affects the activity of PTKs, which causes insulin to fail to bind to insulin receptors, and induces insulin resistance. Xanthones and benzophenones are compounds that have been known to have pharmacological activity as antidiabetic. One of the plants containing these compounds is Garcinia cowa. This study aims to know the affinity and inhibition mechanism of PTP1B by xanthones, benzophenones, and triterpenoid in Garcinia cowa, including garcinia cowone K, guttiferone I, 1,7-dihydroxyxanthone, 1-hydroxyl-7 methoxyxanthone, mangostinone, ?-mangostin, cowanol, gacibiphenyl C, friedelin, ?-friedelinol, and oleanane-12-ol in silico by molecular docking and conducted a pre-ADMET study of these compounds. Molecular docking is carried out in several steps including preparation and optimization of the 3D structure of the compound, preparation of the PTP1B receptor 3D structure, method validation, and docking of the compound with PTP1B. The results obtained from the docking of the compound with the PTP1B receptor appears in the form of bond energies, inhibition constant (IC), and hydrogen bonds. The lower the bond energy value, the more stable the bond between the protein and the resulting ligand is. The results showed that the bond energy and IC value of PTP1B with the native ligand is -10,07 kcal/mol and 0,0417 ?M. Meanwhile the ?-mangostin compound is -8,91 kcal/mol and 0,29317 ?M. It shows that the ?-mangostin has potential as an antidiabetic mellitus type 2 agent by inhibiting PTP1B. In addition, ?-mangostin also shows a good ADMET profile. Keywords: antidiabetic, molecular docking, PTP1B, type 2 diabetes mellitus, xanthones

Osseointegration is a complex process that involves the interaction of dental implants, bone, and the immune system. Preclinical testing was carried out to develop a better understanding of the mechanism. Micro-computed tomography (micro-CT) imaging techniques and immunohistochemistry are excellent tools for this objective as both enable quantitative assessment of bone microarchitecture and intercellular interaction. An extensive literature search was conducted using the databases PubMed, Science Direct, Wiley Online, Proquest and Ebscohost from January 2011 to January 2021. Among the publications retrieved, the rat model was the most frequently used experimental protocol, with the tibia being the most frequently implanted site. The region of interest demonstrates a high degree of homogeneity as measured by trabecula but varies in size and shape. The most frequently mentioned micro-CT bone parameter and immunohistochemistry bone markers were bone volume per total volume (BV/TV) and runt-related transcription factors (RUNX). Animal models, micro-CT analysis methods, and immunohistochemistry biomarkers yielded a variety of results in the studies. Understanding bone architecture and the remodeling process will aid in the selection of a viable model for a specific research topic.

Objectives: The aim of this case report is to describe radiographically the specific features of periapical cysts to differentiate them from dentigerous cyst lesions despite their similar clinical appearance. Case Report: A 21-year-old female patient came to Dental Hospital in Bandung with a referral for a cone-beam computed tomography (CBCT)  examination with a clinical diagnosis of suspected right mandibular dentigerous cyst and left mandibular periapical cyst. The patient said that during the past month, swelling had appeared on both sides of the jaw, which was getting bigger, the pain was intermittent, and it was disturbing when eating. Intraoral examination showed gingival enlargement, muccobucal fold disappeared. Extraoral examination, facial asymmetry was found due to unilateral swelling.  Radiographic examinations showed both lesions were oval, unilocular, radiolucent internal structures with an average density of 4.7-32 HU resembling soft tissue density, corticated or radiopaque borders, caused expansion of the mandibular corpus buccally and lingually and to mesial and distal, cortical thinning and displacement of the inferior mandibular canal. Conclusion: Lesions on the jaws have almost the same clinical appearance, but through CBCT examination the type of lesion can be well determined. Periapical cyst lesion with large size has a clinical appearance like dentigerous lesions, but radiographically will show a different specific picture.

Hipertensi emergensi merujuk pada kondisi di mana tekanan darah naik secara tiba-tiba dan signifikan dalam waktu singkat. Penderita hipertensi perlu meningkatkan kepatuhan terhadap terapi farmakologi dan non farmakologi untuk mencapai tekanan darah yang normal. Gaya hidup yang tidak sehat, konsumsi natrium yang tinggi serta ketidakpatuhan mengkonsumsi obat antihipertensi menjadikan tekanan darah cenderung semakin meningkat. Tujuan penelitian ini untuk mengidentifikasi faktor-faktor yang terkait dengan hipertensi emergensi di Unit Gawat Darurat RSUD DR. H. Soemarno Sosroatmodjo Tanjung Selor. Penelitian ini menggunakan jenis penelitian observasional analitik. Penelitian ini menggunakan desain studi cross-sectional. Populasi yang dijadikan sampel dalam penelitian ini adalah pasien dengan hipertensi yang datang ke Unit Gawat Darurat RSUD DR. H. Soemarno Sosroatmodjo Tanjung Selor. Teknik pengambilan sampel dalam penelitian ini menggunakan purposive sampling. Penelitian ini melibatkan 24 orang sebagai sampel. Diperoleh sebagian besar responden pola makan kurang baik sebanyak 13 orang (54,2%), kepatuhan minum obat tinggi sebanyak 15 orang (62,5%) dan stres sedang sebanyak 14 orang (58,3%), stres ringan sebanyak 10 orang (41,7%) dan mengalami hipertensi emergensi sebanyak 17 orang (70,8%). Terdapat korelasi antara pola makan, tingkat stres, dan kepatuhan dalam minum obat dengan kejadian hipertensi emergensi.

Most complaints in dentistry today are about swelling and mobility of the tooth, and the diagnosis of an inflammatory lesion is generally made in both complaints. Burkitt's lymphoma (BL) is a type of malignant tumor classified as Non-Hodgkin's Lymphoma (NHL) with clinical symptoms of swelling dan tooth mobility similar to the inflammatory lesions. This paper aims to describe the similarities between inflammatory lesions and Burkitt's lymphoma. Burkitt's lymphoma can be classified into endemic, sporadic, and human immunodeficiency-related. Sporadic BL (sBL) occurs in approximately 12 to 30% of maxillofacial patients and commonly affects children. Several case studies reported that the clinical symptom of sBL is swelling. It has been reported in Europe and Asia that sBL in children shows swelling and tooth mobility in the maxillary and mandibular regions. Enlargement and redness of gingival tissue, hypermobility of the tooth, and swelling of the gingival around the painful tooth were reported as sBL cases after some examination. Inflammatory lesions such as BL-like have similar clinical symptoms, so the dentist must be careful in diagnosing cases of swelling and tooth mobility.