Administering medicines to 0- to 5-year-old children in a resource-limited environment requires dosage forms that circumvent swallowing solids, avoid on-field reconstitution, and are thermostable, cheap, versatile, and taste masking. We present a strategy that stands to solve this multifaceted problem. As many drugs lack adequate water solubility, our formulations used oils, whose textures could be modified with gelling agents to form “oleogels.” In a clinical study, we showed that the oleogels can be formulated to be as fluid as thickened beverages and as stiff as yogurt puddings. In swine, oleogels could deliver four drugs ranging three orders of magnitude in their water solubilities and two orders of magnitude in their partition coefficients. Oleogels could be stabilized at 40°C for prolonged durations and used without redispersion. Last, we developed a macrofluidic system enabling fixed and metered dosing. We anticipate that this platform could be adopted for pediatric dosing, palliative care, and gastrointestinal disease applications.

Makeup chemistries have evolved over the recent years and have become more long-wearing, waterproof and difficult to remove. Thus, many changes have occurred among products designed to remove makeup. Specifically, the facial cleansing/makeup remover wipes category is challenged to establish new strategies and adapt to the changing consumer needs and the evolving competitive landscape. A global product category review can provide the upfront understanding necessary to establish fundamental knowledge. That knowledge can in turn be leveraged when developing future products. A customized descriptive analysis method was applied to address the unique challenges of the category. The method leveraged existing methods and was augmented with new descriptive modalities, specific to the unique developments in the category. A total of seventy-one attributes were identified that spanned visual and tactile cues of the wipes, cleansing performance cues during use, as well as skin look and feel attributes after use. Thirteen facial cleansing/makeup remover wipes from global markets were selected for testing based on commercial and historical insights. Three sensorial perceptual maps were generated displaying the profiles of the thirteen products in three areas of product properties—visual and tactile, cleaning performance, and skin look and feel. These study results combined with existing consumer insights helped the R&D team to establish strategies to guide product development for this category.

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