The present study aimed to investigative the micrbiological quality of Brazil nuts sold in open markets in the city of Macapá-AP. Samples of fresh almonds were collected at 3 open markets in Macapá from September to October 2018. Microbiological analyzes for thermotolerant coliforms and Salmonella sp were performed according to procedures described by MAPA (Ministry of Agriculture, Livestock and Supply) 62, of August 26, 2003 and the results compared with RDC nº 12, of January 2, 2001. The results showed the presence of levels of thermotolerant coliforms above the limits established by the legislation in at least one sample of each evaluated fair, being presence of Salmonella sp. The analysis results indicate that all fairs presented unsatisfactory samples, corresponding to 33,33% of the total in fairs I and III and 66,67% at fair II. Therefore, the analyzes point to the need to intensify sanitary inspection, as well as to devise more effective actions to guide and sensitize marketers to adopt good practices in handling this Amazonian delicacy.

Anorexia Nervosa (AN) is an eating disorder that affects adults, young people and children, has a multifactorial etiology, characterized by a distortion of body image associated with fear of gaining weight, leading the individual to commit severe food restriction, causing extreme weight loss and malnutrition. This, clinical and metabolic manifestations associated with inflammatory biomarkers are triggered, based on evidence on the dysregulation of the immune system and an inflammatory immunomodudulation during AN. The present study aims to present evidence that demonstrates how inflammatory mediators are systematically related to the most common clinical manifestations more in AN. This is an integrative review, based on consultation of the databases: MEDLINE and LILACS. Sixteen studies were selected from 2014 to 2020 with 56, 25% NE3, followed by 31, 25% NE 5 and 12, 5% NE 2. Studies have shown that inflammatory biomarkers such as interleukins, and chemokines, leptin, ghrelin, omentine-1, adinonectin, BDNF, VEGF, VCAM, PCR, OC, CTX, OPG, RANK, RANKL, IFN -γ, NO, IGF and some classes of TNF are related to clinical manifestations in AN contributing to prolonged and difficult to reverse symptoms, such as depression, sleep disorders, memory and learning, altered behavior , tissue damage, decreased appetite, risk for cardiovascular disease, changes in the intestinal microbiome, osteoporosis, amenorrhea, inflammation of the hypothalamus, impaired energy metabolism and unregulated inflammatory state. However, further clarification is needed on this topic, as there are still few studies in this line of research.