Care giving is a difficult task especially when it involves physical or mental retardation, and it leaves marked negative impact on primary caregivers. Alzheimer is one such ailment where the patient is totally dependent on others for each bit of their life, so the care giving of Alzheimer patients become more burdensome. The aim of this research was to examine the burden and difficulties of caregivers dealing with Alzheimer's patient, especially those living at home. Case study method was employed for this research. Eight caregivers were selected purposively, and content analysis was used to examine their perspective regarding burden and challenges. In the assessment of content, the gathered qualitative information was analyzed in a deductive manner. The results of the analysis showed that caregivers face daily challenges in terms of physical and psychological health issues, social support and resources, family conflicts, crisis, and criticism. The outcomes further elaborated that due to different roles and responsibilities as caregivers they face both positivity and negativity in their lives which in most cases leads them to religiosity. The results of this study can add to positive social change by contributing to the development and implementation of programs that may take into account considerable differences in future.