Background: The thyroid hormone is a central regulator of body functions; disorder of thyroid functions is considered to cause electrolytic disorders. Thus the main objective of this study is to assess the correlation of thyroid dysfunction with serum electrolyte levels. Methods: In this prospective cross-sectional study,100 patients who attended Manipal Teaching Hospital having thyroid hormones disarrangement were included. Estimation of serum electrolytes were also done in those patients. Patients with subclinical hypothyroidism and subclinical hyperthyroidism were excluded. Thyroid hormones were estimated by electrochemiluminiscence immunoassay (eCLIA) and Serum sodium and potassium was estimated by ion selective electrode (ISE) method.  Data was entered and analyzed using SPSS 23 by Spearman’s correlation test and Chi square test. A p-value of < 0.05 was considered as statistical significance. Results: The 75% of total patients were found to be having hypothyroidism and 25% to have hyperthyroidism. Spearman’s correlation coefficient for Na+ and K+ vs fT3, fT4 showed positive correlation (p-value<0.001) and Na+ and K+ vs TSH showed negative correlation.  There was significant association between Na+ and thyroid hormones (p-value<0.001) but no association between K+ and thyroid hormones. (p-value>0.001). Conclusions: The current study reveals that decrease in thyroid hormones may lead to hyponatremia.  Knowledge of this significant association will be worthwhile value for clinicians, to manage their patients optimally.

Background: Hyperuricemia in thyroid dysfunctions has been linked to either impaired renal handling of uric acid or overproduction of uric acid. This study aimed to determine the serum uric acid levels in patients with thyroid dysfunction and to determine the link between thyroid dysfunction and hyperuricemia. Methods: This prospective and quantitative study which was conducted at Department of Biochemistry, Manipal Teaching Hospital determined the serum uric acid concentrations of 30 years or older; male or female participants diagnosed with either hypothyroidism or hyperthyroidism. T3 and T4 was determined by chemiluminiscence immunoassay (CLIA) and OCD VITROS dry chemistry analyzer was used to determine serum uric acid level. Data entry and analysis was done using SPSS version 23. Descriptive statistics using frequency with percentage and inferential statistics using non-parametric tests were used. Results: In a total of 100 participants, prevalence of hyperuricemia was 42% (31% in hypothyroidism and 11% in hyperthyroidism). The mean serum uric acid in overall participants was 6.25 ± 2.04 (6.55 ± 1.84 in hypothyroidism and 6.05 ± 1.71 in hyperthyroidism).Significant association was seen between thyroid status and hyperuricemia (p = 0.001).Also, significant difference (p = 0.02) was seen in serum uric acid between hyperthyroid and hypothyroid patients. Conclusion: Higher prevalence rate of hyperuricemia was found among hypothyroid patients than in hyperthyroid subjects, and a significant association was found between thyroid dysfunction and hyperuricemia. This indicates need for more research to further uncover the mechanisms underlying it.